中药单体及有效成分对人永生化角质形成细胞作用的实验研究进展  

Experimental Research Progress on the Effects of Traditional Chinese Medicine Monomers and Active Components on Human Immortalized Keratinocytes

作　　者：王磊[1] 刘宇超 代博文 张华超 李锘[1] 白彦萍[1] WANG Lei;LIU Yuchao;DAI Bowen;ZHANG Huachao;LI Nuo;BAI Yanping

机构地区：[1]中日友好医院皮肤病与性病科,北京100029 [2]北京中医药大学研究生院,北京100029

出　　处：《新中医》2022年第5期34-37,共4页New Chinese Medicine

基　　金：国家自然科学基金面上项目(82074445);国家自然科学基金青年项目(81904210);中日友好医院院级课题(2017-1-QN-9)。

摘　　要：中医药治疗银屑病具有独特的疗效,中药单体及有效成分干预人永生化角质形成(HaCaT)细胞的增殖及凋亡,调控信号转导通路及调节细胞免疫功能等方面取得一定成效。该文通过阅读近10年国内外具有代表性的文献,分析中药作用于HaCaT细胞的单体有效成分。常用中药单体包括柴胡皂苷、重楼皂苷Ⅰ、白芍总苷、紫草素、苦参碱、丹皮酚、姜黄素、熊果酸等。从中药单体对HaCaT细胞研究进展概括出发,阐述其相应的作用机制,以求为中药单体治疗银屑病的相关研究提供参考。Traditional Chinese medicine has a unique curative effect on psoriasis.Traditional Chinese medicine monomers and effective components have achieved certain results in interfering with the proliferation and apoptosis of human immortalized keratinocytes(HaCaT),regulating signal transduction pathway and regulating cellular immune function.Autor analyzes the monomer active components of traditional Chinese medicine acting on HaCaT cells by reading the representative literatures at home and abroad in recent 10 years.Common Chinese medicine monomers include saikosaponin,PolyphyllinⅠ,total glucosides of paeony,shikonin,matrine,paeonol,curcumin,ursolic acid,etc.Starting from the research progress of traditional Chinese medicine monomer on HaCaT cells,this paper expounds its corresponding mechanism,in order to provide reference for the research of traditional Chinese medicine monomer in the treatment of psoriasis.

关 键 词：银屑病 中药单体 人永生化角质形成细胞 增殖 凋亡 

分 类 号：R284[医药卫生—中药学]