消囊调经汤联合屈螺酮炔雌醇片(Ⅱ)治疗多囊卵巢综合征临床研究  

Clinical Study on Xiaonang Tiaojing Tang Combined with Drospirenone and Ethinylestradiol Tablets(Ⅱ)for Polycystic Ovary Syndrome

作　　者：李燕红[1,3] 郭梅珍[1,3] 袁俊俊 周艳艳[2,4] LI Yanhong;GUO Meizhen;YUAN Junjun;ZHOU Yanyan

机构地区：[1]黄河科技学院,河南郑州450000 [2]河南中医药大学,河南郑州450000 [3]黄河科技学院附属医院,河南郑州450000 [4]河南中医药大学第二附属医院,河南郑州450000

出　　处：《新中医》2022年第5期135-139,共5页New Chinese Medicine

基　　金：河南省科技攻关项目(212102311138)。

摘　　要：目的:观察消囊调经汤联合屈螺酮炔雌醇片(Ⅱ)对多囊卵巢综合征(PCOS)患者的临床疗效及对抗缪勒管激素(AMH)、子宫内膜容受性的影响。方法:选取90例PCOS患者,按随机数字表法分为对照组及观察组各45例,对照组予以屈螺酮炔雌醇片(Ⅱ)常规治疗,观察组在对照组基础上加用消囊调经汤,2组均连续服用3个月。比较2组治疗前后中医证候积分、卵巢体积、优质卵数目及窦卵泡数目、性激素水平[促黄体生成素(LH)、促泡激素(FSH)、雌二醇(E_(2))、睾酮(T)、孕酮(PRG)及垂体泌乳素(PRL)]、血清AMH、子宫内膜容受性的变化。结果:治疗后,2组中医证候的主症积分、次症积分及总积分均较治疗前降低(P<0.05),观察组上述3项积分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组卵巢体积、窦卵泡数目均较治疗前下降,优质卵数目均较治疗前上升,差异均有统计学意义(P<0.05);观察组卵巢体积及窦卵泡数目均低于对照组,优质卵数目高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组LH、T、PRG、PRL、FSH水平均较治疗前下降,E_(2)水平均较治疗前上升(P<0.05);观察组LH、T、PRG、PRL、FSH水平均低于对照组,E_(2)水平高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清AMH水平、子宫动脉PI及RI均较治疗前降低(P<0.05),子宫内膜厚度均较治疗前增加(P<0.05);观察组血清AMH水平、子宫动脉PI及RI均低于对照组,子宫内膜厚度高于对照组,差异均有统计学意义(P<0.05)。结论:消囊调经汤联合屈螺酮炔雌醇片(Ⅱ)可有效缓解PCOS临床症状,改善卵巢储备功能,促进卵泡发育,改善子宫容受性。Objective:To observe the clinical effect of Xiaonang Tiaojing tang combined with drospirenone and ethinylestradiol tablets(Ⅱ)for patients with polycystic ovary syndrome(PCOS)and its effect on anti-mullerian hormone(AMH)and endometrial receptivity.Methods:A total of 90 cases of PCOS patients were selected and divided into the control group and the observation group according to the random number table method,with 45 cases in each group.The control group was given drospirenone and ethinylestradiol tablets(II)for routine treatment,and the observation group was additionally given Xiaonang Tiaojing tang based on the treatment of the control group.Before and after treatment,the changes of Chinese medicine syndrome scores,ovarian volumes,numbers of high-quality eggs and antral follicles,hormone levels including luteinizing hormone(LH),follicle-stimulating hormone(FSH),estradiol(E_(2)),testosterone(T),progesterone(PRG)and prolactin(PRL),serum AMH and endometrial receptivity in the two groups were compared.Results:After treatment,the scores of primary and secondary symptoms of Chinese medicine syndromes as well as the total scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group,differences being significant(P<0.05).After treatment,the ovarian volumes and the numbers of antral follicles in the two groups were decreased when compared with those before treatment,and the numbers of high-quality eggs were increased,differences being significant(P<0.05);the ovarian volume and the number of antral follicles in the observation group were lower than those in the control group,and the number of high-quality eggs was higher,differences being significant(P<0.05).After treatment,the levels of LH,T,PRG,PRL and FSH in the two groups were decreased when compared with those before treatment,and E_(2) levels were increased(P<0.05);the levels of LH,T,PRG,PRL and FSH in the observation group were lower than those in t

关 键 词：多囊卵巢综合征 屈螺酮炔雌醇片(Ⅱ) 消囊调经汤 抗缪勒管激素 子宫内膜容受性 

分 类 号：R711.75[医药卫生—妇产科学]