加味六味地黄汤治疗肝肾亏虚型糖尿病性骨质疏松症的临床疗效  

Clinical Efficacy of Jiawei Liuwei Dihuang Decoction Combined with Alendronate on the Treatment of Diabetic Osteoporosis with Liver-Kidney Depletion Pattern

作　　者：刘明明 马勇[2] 许海燕 郭杨[2] 吕南宁 程建[4] LIU Mingming;MA Yong;XU Haiyan;GUO Yang;LYU Nanning;CHENG Jian(Lianyungang Clinical College of Xuzhou Medical University,Lianyungang 222003,Jiangsu China;Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210004,China;Basic Medical College of Xuzhou Medical University,Xuzhou 221004,Jiangsu China;Xuzhou Central Hospital,Xuzhou 221009,Jiangsu China)

机构地区：[1]徐州医科大学连云港临床学院/连云港市第二人民医院,江苏连云港222003 [2]南京中医药大学附属医院 [3]徐州医科大学基础医学院 [4]徐州市中心医院/南京中医药大学附属徐州市中心医院

出　　处：《中国中医骨伤科杂志》2022年第3期12-16,20,共6页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：江苏省自然科学基金(BK20180996);江苏省中医药局一般项目(YB201964);连云港市卫健委课题面上项目(201915)。

摘　　要：目的:探讨应用加味六味地黄汤治疗肝肾亏虚型糖尿病性骨质疏松症患者的临床疗效。方法:将2018年6月至2020年6月收治的60例糖尿病性骨质疏松症患者随机分为两组,每组30例。对照组中男16例,女14例,口服阿仑膦酸钠片治疗;观察组中男14例,女16例,口服加味六味地黄汤治疗。两组患者均常规口服碳酸钙,疗程为4个月,分析比较两组患者治疗前后的疼痛视觉模拟评分(VAS)、健康调查简表(SF-36)评分、糖脂代谢、骨代谢及骨密度等相关指标。结果:两组患者治疗后VAS评分均较治疗前有改善,差异有统计学意义(P<0.05),但两组间改善程度差异无统计学意义(P>0.05);两组患者治疗后SF-36评分、糖代谢及骨代谢指标均较治疗前好转,差异有统计学意义(P<0.05),同时观察组改善情况较对照组更好,差异有统计学意义(P<0.05);两组患者治疗后脂代谢及骨密度较治疗前差异无统计学意义(P>0.05)。结论:加味六味地黄汤治疗肝肾亏虚型糖尿病性骨质疏松症,可以改善机体骨代谢和糖代谢,减轻腰背部疼痛,提高患者生活质量,较单纯口服阿仑膦酸钠片效果更佳。Objective:To explore the clinical efficacy of Jiawei Liuwei Dihuang decoction combined with alendronate on the treatment of diabetic osteoporosis with liver-kidney depletion.Methods:60 patients with diabetic osteoporosis from June 2018 to June 2020 were randomly divided into two groups with 30 patients in each group.In the control group 16 males and 14 females were treated with oral alendronate.In the observation group 14 males and 16 females were treated with Jiawei Liuwei Dihuang decoction.All patients were treated with calcium carbonate orally.The treatment course in both groups was 4 months, and then the visual analogue scale(VAS), short form 36-item health survey(SF-36) score, glucose and lipid metabolism, bone mineral density and bone metabolism were compared between the two groups before and after treatment.Results:The WAS scores of the two groups after treatment were significantly improved than those before treatment(P<0.05), but there was no significant difference in the degree of improvement between the two groups(P>0.05).The SF-36 score, glucose metabolism and bone metabolism of the two groups were significantly improved after treatment(P<0.05), and the improvement of the observation group was more obvious than that of control group, and the difference was statistically significant(P<0.05).There was no significant difference in lipid metabolism and bone mineral density between the two groups after treatment(P>0.05).Conclusion:The application of Jiawei Liuwei Dihuang decoction combined with alendronate on the treatment of diabetic osteoporosis with liver-kidney depletion can effectively improve bone metabolism and glucose metabolism, reduce low back pain and improve the quality of life of patients, which is better than oral alendronate alone.

关 键 词：加味六味地黄汤 阿仑膦酸钠 糖尿病性骨质疏松症 肝肾亏虚证 骨代谢 

分 类 号：R274.39[医药卫生—中医骨伤科学]