TLR2免疫调节作用的研究进展  

Research progress on the TLR2 immunomodulatory effect

作　　者：李冬璇 韩秋菊[1] 张建[1] LI Dong-xuan;HAN Qiu-ju;ZHANG Jian(Institute of Immunopharmaceutical Sciences,School of Pharmaceutical Sciences Shandong University,Jinan 250012,China)

机构地区：[1]山东大学药学院免疫药物学研究所,济南250012

出　　处：《现代免疫学》2022年第1期82-85,共4页Current Immunology

基　　金：国家自然科学基金面上项目(81972686,81972694);传染病防治科技重大专项(2018ZX10301401);山东省重点研发计划(公益性科技攻关类)(2019GSF107068);山东省自然科学基金(ZR2017BH029)资助项目。

摘　　要：TLR2是PRR中TLR家族成员之一,可识别PAMP,以及损伤相关分子模式(damage-associated molecular pattern,DAMP)。在机体免疫微环境中,TLR2信号通路能够影响DC、巨噬细胞、NK细胞、T细胞、肥大细胞等的表型和功能,从而影响机体清除病原体及抗肿瘤能力。目前围绕TLR2通过免疫系统影响疾病进程的研究发展迅速,其已经成为多种疾病治疗的潜在靶点。该文主要综述了TLR2在多种免疫细胞中的作用,包括其对免疫细胞增殖、活化以及功能的影响,及其如何通过诱导细胞因子、趋化因子等信号分子的合成和释放促进免疫细胞间的相互作用及疾病调控进程。TLR2 is a member of the TLR family,which recognizes PAMP as well as damage-associated molecular pattern(DAMP).TLR2 signaling pathway can regulate the phenotype and function of a wide array of immune cells like DC,macrophage,NK cell,T cell,mast cell to enable them to perform more effectively anti-pathogen and anti-tumor functions.Recently,researches about the involvements of TLR2 in the development and treatment of many diseases progress rapidly and become the potential target for many diseases.This review summarized comprehensively multiple roles of TLR2 in immune responses at the cellular,molecular and functional levels.

关 键 词：TOLL样受体2 免疫细胞 病原体相关分子模式 损伤相关分子模式 

分 类 号：R392.5[医药卫生—免疫学]