蛋白质组学及其在肝癌诊疗中的研究进展  

Proteomics and its research progress in diagnosis and treatment of hepatocellular carcinoma

作　　者：郑鑫 郑天宇 ZHENG Xin;ZHENG Tian-yu(Qingdao West Coast New Area Central Hospital,Qingdao 266555,China;College of Urban and Environmental Sciences,Peking University,Beijing 100871,China)

机构地区：[1]青岛西海岸新区中心医院,青岛266555 [2]北京大学城市与环境学院,北京100871

出　　处：《药物分析杂志》2022年第2期179-186,共8页Chinese Journal of Pharmaceutical Analysis

摘　　要：蛋白质组学是一门在大规模水平上研究某一类型细胞、组织或体液中的所有蛋白质组成及其功能的新兴学科。其以细胞或器官表达的所有蛋白质为研究对象,通过凝胶电泳、生物质谱及生物信息学等技术,达到分离、鉴定、分析蛋白质的目的。肝癌是世界上病死率较高的恶性肿瘤之一,运用蛋白质组学技术,可以了解肝癌的发生、发展机制,在诊断和治疗方面产生价值。本文将解释蛋白质组学的概念及主要技术,介绍蛋白质组学在肝癌研究中的意义,阐述蛋白质组学在肝癌的早期诊断,标记物的筛选以及药物靶标的选择中体现出的重要应用。随着蛋白质组学的逐步完善和现代生物技术的迅速发展,这项技术将在肝癌等生命科学领域发挥更显著的作用。Proteomics is a new discipline that studies on all the protein components and their functions in a particular type of cell,tissue or body fluid on a large scale.Its target cells are all proteins expressed in cells or organs,and the proteins are separated,identified and analyzed by gel electrophoresis,bio-mass spectrometry and bioinformatics.Hepatocellular carcinoma is one of the most malignant tumors in the world.Using proteomics technology can understand the occurrence and development of liver cancer and bring value in diagnosis and treatment.This article will explain the concept and major technologies of proteomics,introduce the significance of proteomics in the study of liver cancer,and expound the important application of proteomics in the early diagnosis of liver cancer,selection of screening markers and selection of drug targets.With the gradual improvement of proteomics and the rapid development of modern biotechnology,this technology will play a more significant role in the life sciences such as liver cancer.

关 键 词：蛋白质组学 肝癌 生物学标记 药物作用靶标 转移复发机理 胶电泳 生物质谱 生物信息学 研究进展 

分 类 号：R917[医药卫生—药物分析学]