加减阳和汤联合泼尼松龙治疗浆细胞性乳腺炎临床研究  

Clinical Study on Modified Yanghe Tang Combined with Prednisolone for Plasma Cell Mastitis

作　　者：范国才 王卫华[2] FAN Guocai;WANG Weihua

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]遂昌县人民医院,浙江遂昌323300

出　　处：《新中医》2022年第4期21-24,共4页New Chinese Medicine

摘　　要：目的:观察加减阳和汤联合泼尼松龙治疗浆细胞性乳腺炎的临床效果。方法:将73例浆细胞乳腺炎患者随机分为治疗组38例和对照组35例。2组均给予替硝唑抗感染治疗,对有脓肿形成者给予手术切排治疗,对照组在此基础上给予泼尼松龙治疗,治疗组在对照组的础上采用加减阳和汤治疗。比较2组治疗效果、乳房疼痛症状、乳腺肿块皮肤变化、血清催乳素(PRL)水平及复发率。结果:治疗组总有效率为94.74%,对照组为74.29%,2组比较,差异有统计学意义(P<0.05)。随访12个月,治疗组复发率为5.26%,对照组为25.71%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组乳房疼痛评分均较治疗前降低(P<0.05),且治疗组乳房疼痛评分低于对照组(P<0.05)。治疗后,2组乳腺肿块皮肤变化评分均较治疗前降低(P<0.05),且治疗组评分低于对照组(P<0.05)。治疗后,2组血清PRL水平均较治疗前降低(P<0.05),且治疗组PRL水平显著低于对照组(P<0.05)。结论:加减阳和汤联合泼尼松龙治疗浆细胞性乳腺炎疗效显著,可有效减轻乳房疼痛,改善乳腺肿块皮肤状态,降低PRL分泌水平,且复发率较低。Objective:To observe the clinical effect of modified Yanghe tang combined prednisolone forplasma cell mastitis.Methods:A total of 73 cases of patients with plasma cell mastitis were randomly divided into the treatment group and the control group,with 38 and 35 cases in each group respectively.Both groups were treated with tinidazole for anti infection,and those with abscess were treated with surgical resection.The control group was treated with prednisolone on this basis,and the treatment group was treated with modified Yanghe tang on the basis of the control group.The symptoms of breast pain,changes of skin in breast mass,and levels of prolactin(PRL)in serum before and after treatment as well as clinical effects and recurrence rates in the two groups were compared.Results:The total effective rate was 94.74%in the treatment group and 74.29%in the control group,the difference being significant(P<0.05).After 12-month follow-up,the total recurrence rate was 5.26%in the treatment group and 25.71%in the control group,the difference being significant(P<0.05).After treatment,the scores of breast pain in the two groups were decreased when compared with those before treatment(P<0.05),and the score of breast pain in the treatment group was lower than that in the control group(P<0.05).After treatment,the scores of changes in skin of breast mass in the two groups were decreased when compared with those before treatment(P<0.05),and the score in the treatment group was lower than that in the control group(P<0.05).After treatment,the PRL levels in serum in the two groups were decreased when compared with those before treatment(P<0.05),and PRL level in the treatment group was significantly lower than that in the control group(P<0.05).Conclusion:Modified Yanghe tang combined prednisolone has a significant curative effect in treatingplasma cell mastitis,which can effectively relieve breast pain,improve skin of breast mass and reduce PRL secretion levels with low recurrence rates.

关 键 词：浆细胞性乳腺炎 加减阳和汤 泼尼松龙 疼痛 催乳素 

分 类 号：R655.8[医药卫生—外科学]