醒脑静注射液联合胞磷胆碱钠胶囊治疗重型颅脑损伤疗效观察及对血清CNP、LGF-Ⅱ水平的影响  

Clinical Effect of Xingnaojing Injection Combined with Citicoline Sodium Capsules for Severe Brain Injury and Its Effect on CNP and LGF-Ⅱ in Serum

作　　者：陈运江 高安举[1] CHEN Yunjiang;GAO Anju

机构地区：[1]安阳市人民医院神经外科,河南安阳455000

出　　处：《新中医》2022年第4期106-109,共4页New Chinese Medicine

摘　　要：目的:观察醒脑静注射液联合胞磷胆碱钠胶囊治疗重型颅脑损伤的临床效果及其对血清C型利钠肽(CNP)、胰岛素样生长因子-Ⅱ(LGF-Ⅱ)水平的影响。方法:选取重型颅脑损伤患者92例,随机分为对照组和研究组各46例。2组均行常规治疗,对照组加用胞磷胆碱钠胶囊治疗,研究组在对照组的基础上加用醒脑静注射液治疗。比较2组临床效果、血清LGF-Ⅱ、CNP含量,评估2组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、多伦多临床评分系统(CSS)评分、Bathel指数水平。结果:研究组总有效率为95.7%,对照组为78.3%,2组比较,差异有统计学意义(P<0.05)。治疗后,研究组血清LGF-Ⅱ、CNP水平均高于对照组,差异有统计学意义(P<0.05)。治疗前,2组NIHSS、CSS评分及Bathel指数比较,差异无统计学意义(P>0.05);治疗后,研究组NIHSS、CSS评分均低于对照组(P<0.05),Bathel指数高于对照组(P<0.05)。结论:醒脑静注射液联合胞磷胆碱钠胶囊治疗重型颅脑损伤,可提高临床治疗效果及血清CNP、LGF-Ⅱ水平,改善患者神经功能。Objective:To observe the clinical effect of Xingnaojing injection combined with citicoline sodium capsules for severe brain injury and its effect on contents of C-type natriuretic peptide(CNP) and insulin-like growth factor Ⅱ(LGF-Ⅱ) in serum.Methods:A total of 92 cases of patients with severe brain injury were selected and randomly divided into the control group and the study group,with 46 cases in each group.Both groups were given routine treatment;the control group was additionally treated with citicoline sodium capsules,and the study group was additionally treated with Xingnaojing injection based on the treatment of the control group.The clinical effects and the contents of LGF-Ⅱ and CNP in serum in the two groups were compared.Before and after treatment,the scores of National Institutes of Health Stroke Scale(NIHSS) and Toronto Clinical Scoring System(CSS),and Barthel index in the two groups were evaluated.Results:The total effective rate was 95.7% in the study group and 78.3% in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of LGF-Ⅱ and CNP in serum between the two groups(P>0.05);after treatment,the levels of LGF-Ⅱ and CNP in serum in the study group were higher than those in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of NIHSS and CSS and the Barthel index(P>0.05);after treatment,the scores of NIHSS and CSS in the study group were lower than those in the control group(P<0.05),and the Barthel index was higher(P<0.05).Conclusion:Xingnaojing injection combined with citicoline sodium capsules for severe brain injury can improve the clinical effect,the levels of CNP and LGF-Ⅱ in serum and the neurological function.

关 键 词：重型颅脑损伤 醒脑静注射液 胞磷胆碱钠胶囊 C型利钠肽 胰岛素样生长因子-Ⅱ 

分 类 号：R651.15[医药卫生—外科学]