附子现代药理研究及临床应用差异探讨  

Study on Difference of Modern Pharmacology and Clinical Application of Radix Aconiti Lateralis Praeparata

作　　者：曾祥珲[1] 谢庆凤[1] 颜芳[1] 陈党红[1] ZENG Xianghui;XIE Qingfeng;YAN Fang;CHEN Danghong

机构地区：[1]广东省中医院,广东广州510370

出　　处：《新中医》2022年第4期159-163,共5页New Chinese Medicine

基　　金：国家中医药管理局制订中医经典病房建设指南(GZY-YZS-2018-27);广东省中医院齐玉茹学术经验传承工作室(中医二院〔2015〕37号-4)。

摘　　要：附子的峻烈之性和毒性反应与其疗效的关系是临床争议的焦点。现代药理研究表明,附子的毒性主要与乌头碱以及次乌头碱的含量有关,具有明确的毒性和致死性。附子的现代药理研究和临床应用存在较大的差异,若只从药理学的角度来看待附子的主要成分以及其“毒性”,并不能指导临床的辨证用药。中医认为,附子能激发人体元气,激荡人体阴阳气血,推动气机的升降出入,是一味不可多得的、攻邪峻猛的良药。以中医的辨证思维来理解附子的“毒性”,能给临床用药提供更多的指导意见。The relationship between the drastic nature and toxic reactions of Radix Aconiti Lateralis Praeparata and its curative effect is the focus of clinical controversy.Modern pharmacological studies show that the toxicity of Radix Aconiti Lateralis Praeparata is mainly related to the content of aconite aconite and hypaconitine,with clear toxicity and lethality.Because of the great difference between the modern pharmacological research and clinical application of Radix Aconiti Lateralis Praeparata,the main components and toxicity of it from the perspective of pharmacology cannot guide the clinical use of syndrome differentiation.According to Chinese medicine,Radix Aconiti Lateralis Praeparata can motivate the original qi of the human body,stimulate the yin,yang,qi and blood,and promote the ascending,descending,exiting and entering of qi movement,which is a kind of drastic but good herbs to attack the pathogenic factors.Understanding the "toxicity" of aconite by dialectical thinking of traditional Chinese medicine can provide more guidance for clinical practice.

关 键 词：附子 毒性 临床应用 

分 类 号：R282.7[医药卫生—中药学]