冠状动脉粥样硬化性心脏病患者可溶性高级糖基化终末产物受体与肾功能的相关性分析  

Correlation analysis of soluble advanced glycation end product receptors and renal function in patients with coronary atherosclerotic heart disease

作　　者：陈璐 郭新颖[1] 刘建 杜凤和[2] 郭彩霞 Chen Lu;Guo Xinying;Liu Jian;Du Fenghe;Guo Caixia(Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China)

机构地区：[1]首都医科大学附属北京同仁医院心血管中心,北京100730 [2]首都医科大学附属北京天坛医院老年科,北京100070

出　　处：《首都医科大学学报》2022年第2期167-172,共6页Journal of Capital Medical University

基　　金：国家自然科学基金(82171080,81870265);中国中青年临床研究基金(2017-CCA-VG-045)。

摘　　要：目的探讨冠状动脉粥样硬化性心脏病(以下简称冠心病)患者可溶性高级糖基化终末产物受体(soluble receptor for advanced glycation end products,sRAGE)浓度和肾功能的相关性。方法在行冠状动脉造影确诊冠心病的人群中,根据估算的肾小球滤过率(estimated glomerular filtration rate,eGFR)分为肾功能正常组和肾功能下降组,比较2组临床特征、sRAGE浓度,采用Spearman相关及Logistic回归分析血浆sRAGE浓度和肾功能的相关性。结果本研究共纳入170例冠心病患者,相关性分析结果提示sRAGE与肌酐呈正相关(r=0.152,P=0.048),sRAGE与尿素氮呈正相关(r=0.160,P=0.038),sRAGE与eGFR呈负相关(r=-0.185,P=0.016)。肾功能正常组109例,肾功能下降组61例。与肾功能正常组相比,肾功能下降组sRAGE浓度增加[(2.00±0.61)μg/L vs(1.70±0.60)μg/L],差异有统计学意义(P=0.003)。多因素Logistic回归分析提示sRAGE是冠心病患者肾功能下降的关联指标(OR=2.954,95%CI:1.030~8.474,P=0.044)。结论血浆sRAGE浓度可能在冠心病伴发肾功能下降中具有潜在指示物的作用。Objective To evaluate the correlation between soluble receptor for advanced glycation end products(sRAGE)and renal function in patients with coronary atherosclerotic heart disease(CHD).Methods This study was a cross-sectional study.Plasma sRAGE and renal function indexes were detected in patients diagnosed with CHD who underwent coronary angiography in hospital.According to estimated glomerular filtration rate(eGFR),patients were divided into normal renal function group and decreased renal function group.Clinical characteristics and sRAGE levels of the two groups were compared,and the correlation between plasma sRAGE levels and renal function was analyzed by Spearman correlation and Logistic regression.Results A total of 170 patients were enrolled in the study.Correlation analysis showed that sRAGE was positively correlated to creatinine(r=0.152,P=0.048)and blood urea nitrogen(r=0.160,P=0.038),but negatively correlated to eGFR(r=-0.185,P=0.016).There were 109 patients in normal renal function group and 61 patients in decreased renal function group.Compared with the normal renal function group,sRAGE level was increased[(2.00±0.61)μg/L vs(1.70±0.60)μg/L,P=0.003]in the decreased renal function group.Multivariate Logistic regression analysis showed that sRAGE was correlated to decreased renal function in patients with CHD(OR=2.954,95%CI:1.030-8.474,P=0.044).Conclusion Plasma sRAGE might be a potential indicator for decreased renal function in CHD patients.

关 键 词：可溶性高级糖基化终末产物受体 冠状动脉粥样硬化性心脏病 肾功能 

分 类 号：R541.4[医药卫生—心血管疾病]