99例伏立康唑致视觉损害病例分析  

Analysis of 99 cases of voriconazole-induced visual impairment

作　　者：任晓蕾[1] 张晓[2] 詹轶秋[1] 张春燕[1] 封宇飞 REN Xiao-lei;ZHANG Xiao;ZHAN Yi-qiu;ZHANG Chun-yan;FENG Yu-fei(Department of Pharmacy,People's Hospital,Peking University,Beijing 100044,China;Beijing Center for Adverse Drug Reaction Monitoring,Beijing100024,China)

机构地区：[1]北京大学人民医院药剂科,北京100044 [2]北京市药品不良反应监测中心,北京100024

出　　处：《中国临床药理学杂志》2022年第6期589-591,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的了解伏立康唑致视觉损害的发生特点和规律,为临床安全使用伏立康唑及出现视觉损害时的处置提供指导。方法对2011-01-01至2021-06-30北京市药品不良反应监测中心收集的医疗机构报告的99例伏立康唑导致视觉损害的ADR报告进行回顾性分析。结果99例视觉损害药物不良反应报告中男性54例,女性45例,年龄最小10岁,最大95岁,平均年龄(59.55±19.42)岁。52例为静脉滴注给药,47例为口服给药。给药剂量每次0.05~0.5 g。给药频次14例每天1次,85例每天2次。视觉损害的临床表现位于前3位的主要是色视(45.45%)、视物模糊(32.32%)及闪光感(10.10%)。99例患者中93例(93.94%)视觉损害发生在初始用药的一周内。结论医护人员要密切关注伏立康唑致视觉损害的危险因素,根据血药浓度优化给药方案,降低药物不良反应发生率。Objective To understand the characteristics and rules of visual impairment caused by voriconazole, and to provide guidance for the safe use of voriconazole and the treatment of visual impairment. Methods A retrospective analysis was performed on 99 adverse drug reaction(ADR) reports of visual impairment caused by voriconazole collected from medical institutions in Beijing Adverse Drug Reaction Monitoring Center from January 1, 2011 to June 30, 2021. Results Among the 99 ADR cases with visual impairment, 54 were male and 45 were female, with the minimum age of 10 years and the maximum age of 95 years, with an average age of(59.55±19.42) years. Totally 52 cases were given by intravenous drip and 47 cases by oral administration. The dose varied from 0.05 g to 0.5 g each time. The frequency of administration was once a day in 14 cases and twice a day in 85 cases. The top 3 clinical manifestations of visual impairment were chromatism(45.45%), blurred vision(32.32%) and flash sensation(10.10%).Of the 99 patients, 93(93.94%) had visual impairment within one week of initial administration. Conclusion Medical staff should pay close attention to the risk factors of visual impairment caused by voriconazole, and optimize the dosage regimen according to the blood concentration to reduce the occurrence of adverse reactions.

关 键 词：伏立康唑 视觉损害 北京市 

分 类 号：R971[医药卫生—药品]