藏药熏倒牛活性成分研究进展  

Research progress on active ingredients of Tibetan medicine Biebersteinia heterostemon

作　　者：王英 张尚智 刘凤霞 贺莉萍 孙逸来 安志刚 WANG Ying;ZHANG Shangzhi;LIU Fengxia;HE Liping;SUN Yilai;AN Zhigang(Gansu University of Chinese Medicine,Pharmacy Teaching Department,Dingxi Gansu 743000)

机构地区：[1]甘肃中医药大学定西校区药学教学部,甘肃定西743000

出　　处：《中兽医医药杂志》2022年第1期92-96,共5页Journal of Traditional Chinese Veterinary Medicine

基　　金：2020年定西市科技计划项目(DX2020Z04-2);2021年度甘肃省高校大学生就业创业能力提升工程项目(一般项目82)。

摘　　要：文章运用文献分析方法,综述了藏药熏倒牛主要活性成分及含量的研究进展,结果显示,国内外研究者从藏药熏倒牛中已分离鉴定出黄酮类、苯丙素类等7类化合物105种,其中主要活性物质有β-石竹烯、甘香稀、β-榄香酮、2-(3′,4′-dihydroxy-phenyl)-1,3-benzodioxole-5-aldehyde、木犀草素、伞形花内酯-7-O-β-D-葡萄糖苷、槲皮素、伞形花内酯、山羊豆碱、槲皮素-3-O-β-D-葡萄糖苷、5,7,3′-三羟基-8,4′,5′三甲氧基黄酮、木犀草素-7-葡萄糖苷、β-谷甾醇等13种。研究者通过MCI柱色谱、Sephadex LH-20柱色谱、HPLC分离等技术,测定了伞形花内酯-7-O-β-D-葡萄糖苷、2-(3′,4′-dihydroxy-phenyl)-1,3-benzodioxole-5-aldehyde、β-石竹烯、木犀草素等10种主要活性物质的含量。截止目前,藏药熏倒牛药材化学质量控制标准尚未建立,对具体靶向活性成分及药理作用有待进一步深入研究。In this paper,literature analysis was used to review the research progress of the main active components and content of Tibetan medicine Biebersteinia heterostemon.The results showed that 105 compounds including flavonoids,phenylpropanoid and other 7 categories were isolated and identified from Tibetan medicine Biebersteinia heterostemon by domestic and foreign researchers.The main active substance wasβ-caryophyllene,elixene,β-elemenone,2-(3′,4′-dihydroxy-phenyl)-1,3-benzodioxole-5-aldehyde,luteolin,umbelliferone-7-O-β-D-glucoside,quercetin,7-hydroxycoumarin,galegine,quercetin-3-O-β-D-glucoside,5,7,3′-trihydroxy-8,4′,5′-trime-thoxyflavone,luteolin-7-O-glucoside,β-sitosterol,etc.By means of MCI column chromatography,sephadex LH-20 column chromatography and HPLC preparation,the contents of umbelliferone-7-O-β-D-glucoside,2-(3′,4′-dihydroxy-phenyl)-1,3-benzodioxole-5-aldehyde,β-caryophyllene and luteolin were determined.Up to now,the chemical quality control standard of Tibetan medicine Biebersteinia heterostemon has not been established,and the specific targeted active ingredients and pharmacological effects need to be further studied.

关 键 词：藏药 熏倒牛 活性成分 含量 分析 

分 类 号：S853.7[农业科学—临床兽医学]