度洛西汀合成研究进展  

Research Progress in the Synthesis of Duloxetine

作　　者：于晓钟 王立梅[2] 齐斌[1,2] YUXiao-zhong;WANG Li-mei;QI Bin(College of Pharmaceutical Sciences,Medical College,Soochow University,Suzhou 215000,China;School of Biology and Food Engineering,Changshu Institute of Technology,Suzhou 215500,China)

机构地区：[1]苏州大学医学部药学院,苏州215000 [2]常熟理工学院生物与食品工程学院,苏州215500

出　　处：《当代化工》2022年第2期446-450,共5页Contemporary Chemical Industry

基　　金：江苏省科技计划项目(项目编号:BE2020386,BE2018320);苏州市科技计划项目(项目编号:SS2019031)。

摘　　要：抑郁症是以显著而持久的心境低落为主要临床特征的精神类疾病,而全球抑郁症的患者呈现明显上升趋势,已然变成人类重大疾病。盐酸度洛西汀是良好的抑郁症治疗药物,由于原料的不同合成度洛西汀路线较多。综述了化学法和酶催化合成盐酸度洛西汀合成路线,并对各路线进行分析比较。Depression is a psychiatric disease with significant and lasting depression as its main clinical feature. The number of patients with depression worldwide has shown a clear upward trend and has become a major human disease.Duloxetine hydrochloride is a good treatment for depression. Due to the different raw materials, there are many ways to synthesize duloxetine.In this article, the chemical synthesis and enzyme-catalyzed synthetic routes of duloxetine hydrochloride were reviewed, and these routes were analyzed and compared.

关 键 词：度洛西汀 抗抑郁 合成路线 综述 

分 类 号：TQ463[化学工程—制药化工]