外泌体在小儿外科疾病中的研究现状  

Current research status of exosomes in pediatric surgical diseases

作　　者：周滕 金祝 Zhou Teng;Jin Zhu(Affiliated Hospital,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院,遵义563000

出　　处：《中华小儿外科杂志》2022年第2期184-187,共4页Chinese Journal of Pediatric Surgery

基　　金：国家自然科学基金(81760099)。

摘　　要：外泌体(exosome)是由细胞膜内陷形成多泡体后与质膜融合再释放到细胞外的小囊泡,可由多种细胞分泌且广泛存在于不同体液中。外泌体因具有细胞间通讯、遗传物质交换、抗原呈递、调整组织代谢等功能而被广泛关注。目前,外泌体已在成人疾病中进行了广泛研究,但在小儿外科疾病中研究尚少。本综述通过归纳了外泌体在小儿外科疾病(胆道闭锁、先天性巨结肠及儿童肿瘤)的研究发现,外泌体参与了小儿外科疾病的发生发展,外泌体的不同成分是否成为小儿外科不同疾病的检查或治疗靶点,有待进一步的研究。As small vesicles released extracellular after a formation of multivesicles by an invagination of cell membrane and fusion with plasma membrane,exosomes may be secreted by a variety of cells and exist widely in different body fluids.Exosomes have received a lot of attention because of such diverse functions as intercellular communication,genetic material exchange,antigen presentation and tissue metabolism regulation.Currently exosomes have been extensively studied for adult diseases and yet little discussed for pediatric surgical diseases.This review summarized the findings of exosomes in such pediatric surgical diseases as biliary atresia,Hirschsprung disease and pediatric tumors.Exosomes are involved in the occurrence and development of pediatric surgical diseases.And different components of exosomes may become detection or therapeutic targets for different pediatric surgical diseases.Further studies are required.

关 键 词：外泌体 胆道闭锁 先天性巨结肠 儿童 

分 类 号：R726[医药卫生—儿科]