芳基丙酸和苯并噻嗪类非甾体抗炎药的透皮促渗方法  

Permeation-enhancing methods of aryl propionic acid and benzothiazine non-steroidal anti-inflammatory drugs

作　　者：张李静 姜珊珊 张鹏[1] ZHANG Lijing;JIANG Shanshan;ZHANG Peng(Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]沈阳药科大学无涯创新学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2022年第2期218-226,共9页Journal of Shenyang Pharmaceutical University

摘　　要：目的芳基丙酸和苯并噻嗪类非甾体抗炎药是一种强效的解热镇痛抗炎药,常用于类风湿性关节炎和骨关节炎的治疗,将其制成透皮制剂是临床上使用非甾体抗炎药治疗相关疾病的常见手段。对于透皮制剂来说,如何使治疗剂量的药物进入体循环发挥治疗作用引起了越来越多的关注。方法本文首先对芳基丙酸类和苯并噻嗪类非甾体抗炎药透皮制剂的种类,优缺点,目前国内审批的部分芳基丙酸类和苯并噻嗪类非甾体抗炎药透皮制剂进行简单介绍,然后根据芳基丙酸类和苯并噻嗪类非甾体抗炎药透皮制剂所采用的渗透促进方法分别进行详细的阐述。结果和结论破坏皮肤角质层结构及改变药物自身的理化性质两个部分,为芳基丙酸和苯并噻嗪类非甾体抗炎药透皮制剂促渗方法的选取提供参考。Objective Aryl propionic acid and benzothiazine non-steroidal anti-inflammatory drugs are powerful antipyretic analgesic and anti-inflammatory drugs,which are often used in the treatment of rheumatoid arthritis and osteoarthritis.Transdermal preparation is a common means of clinical use of non-steroidal anti-inflammatory drugs to treat related diseases.Methods For transdermal preparations,how to make therapeutic dose of drugs enter the systemic circulation to exert therapeutic effect has attracted more and more attention.In this paper,the types,advantages and disadvantages of aryl propionic acid and benzothiazine NSAIDs transdermal preparations are briefly introduced firstly.And,based on whether the penetration promotion methods used in the aryl propionic acid and benzothiazine NSAIDs transdermal preparations destroys the stratum corneum,they can be divided into two parts:destroying the structure of the skin stratum corneum and changing the physical and chemical properties of the drug itself.Results and conclusionsAt the following sections,these two parts are elaborated separately to provide a knowledge background for the subsequent selection of permeation-enhancing methods of aryl propionic acid and benzothiazine NSAIDs transdermal preparations.

关 键 词：芳基丙酸类非甾体抗炎药 苯并噻嗪类非甾体抗炎药 透皮制剂 促渗方法 

分 类 号：R917[医药卫生—药物分析学]