过渡金属掺杂磁性纳米粒子在生物医学领域中的研究进展  

Applications of Transition Metal⁃doped Iron⁃based Nanoparticles in Biomedicine

作　　者：杜慧[1,3] 姚晨阳 彭皓 姜波 李顺祥[1] 姚俊烈 郑方 杨方 吴爱国 DU Hui;YAO Chen-Yang;PENG Hao;JIANG Bo;LI Shun-Xiang;YAO Jun-Lie;ZHENG Fang;YANG Fang;WU Ai-Guo(Zhejiang Biomedical Materials Technology and Application International Science and Technology Cooperation Base,Key Laboratory of Magnetic Materials and Devices,Zhejiang Engineering Research Center for ImplantInterventional Materials,Cixi Institute of Biomedical Engineering,Ningbo Institute of Materials Technologyand Engineering,Chinese Academy of Sciences,Ningbo 315201,China;Guangdong Laboratory of Advanced Energy Science and Technology,Huizhou 516000,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院宁波材料科学技术与工程研究所慈溪生物医学工程研究所,浙江省生物医学材料技术与应用国际科技合作基地,中国科学院磁性材料与器件重点实验室,医用植介入材料浙江省工程研究中心,宁波315201 [2]先进能源科学与技术广东省实验室,惠州516000 [3]中国科学院大学,北京100049

出　　处：《应用化学》2022年第3期391-406,共16页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(Nos.32025021,31971292,51873225);国家科技部(Nos.2018YFC0910601,2019YFA0405603);浙江省科技厅(No.2020C03110);宁波市科技局(No.2020Z094)资助

摘　　要：在过去50多年中,磁性纳米粒子(MNPs)由于其可协调的磁性、非侵入性、易操控性和良好的生物相容性等优点得到了广泛的关注。从具有复合结构或不同形状的MNPs的合成方法到与MNPs相关的大量表征技术,其应用领域也与我们的生活紧密相关。然而,MNPs的复杂磁行为受到多种参量的影响,包括粒径、成分、形状和结构等。基于此,通过调节MNPs的主要参量提高其磁功能效果对后续的材料设计和应用具有重大的参考意义。其中,二价过渡金属离子的掺杂是影响MNPs各种磁性能(如磁矩(μ)、饱和磁化强度(M_(s))、矫顽力(H_(c))、磁晶各向异性(K)和弛豫时间(τ_(N)和τ_(B))等)重要参量之一。因此,本文着重介绍了通过向磁性纳米材料中掺杂过渡金属离子来精确调控其磁性的相关机理研究,并介绍了掺杂过渡金属离子的MNPs在生物成像检测(磁共振成像和磁性粒子成像)、药物精准递送和肿瘤治疗以及生物传感方面的潜在机制和所取得的最新进展,最后总结了目前MNPs所面临的一些挑战以及未来发展的趋势。Magnetic nanomaterials(MNPs)have been extensively studied and applied in the past half century due to their unique properties including coordinated magnetic properties,non-invasive,easy manipulation,and good biocompatibility.However,the complex magnetic behavior of MNPs is influenced by a variety of factors,including particle size,composition,shape,and core-shell structure.Therefore,the main parameters of MNPs are needed to coordinate accordingly for specific applications to improve their effectiveness.Among them,doping of divalent transition metal ions is a crucial parameter affecting various magnetic properties of MNPs such as magnetic moment(μ),saturation magnetization strength(M_(s)),coercivity(H_(c)),magnetic crystal anisotropy(K)and relaxation time(τ_(N) and τ_(B)).Therefore,this review focuses on the mechanism of precisely regulating the magnetic properties of magnetic nanomaterials by doping them with transition metal ions,and introduces the potential mechanisms and some recent advances of MNPs doped with transition metal ions for bioimaging detection(magnetic resonance imaging and magnetic particle imaging),drug precision delivery and tumor therapy,and biosensing.Finally,we summarize some challenges and future trends of MNPs.

关 键 词：磁性纳米材料 过渡金属掺杂 磁协调机理 生物成像 肿瘤治疗 药物递送 生物传感 

分 类 号：O614[理学—无机化学]