慢性血栓栓塞性肺动脉高压:构建动物模型的研究进展  

Chronic Thromboembolic Pulmonary Hypertension:Advances in Constructing Animal Models

作　　者：胡美曦 黄志华 柳志红[1] 赵智慧[1] 罗勤[1] 赵青[1] HU Meixi;HUANG Zhihua;LIU Zhihong;ZHAO Zhihui;LUO Qin;ZHAO Qing(Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)

机构地区：[1]中国医学科学院,北京协和医学院,国家心血管病中心,阜外医院,北京100037

出　　处：《心血管病学进展》2022年第3期236-240,共5页Advances in Cardiovascular Diseases

基　　金：中国医学科学院临床与转化医学研究基金(2020-I2M-C&T-B-055,2021-I2M-C&T-B-032);北京市自然科学基金面上项目(7202168)。

摘　　要：慢性血栓栓塞性肺动脉高压(CTEPH)被认为是急性肺血栓栓塞症的一种长期并发症,然而,研究表明,部分确诊为CTEPH的患者并无症状性肺血栓栓塞的既往病史,提示肺血栓栓塞可能并不是CTEPH的唯一病因。尽管近年来对肺动脉高压的研究取得了广泛的进展,但由于缺乏对CTEPH病理生理学的相关研究,此类患者的综合治疗仍面临许多挑战,且患者的预后不容乐观。因此,建立合理可靠的动物模型以揭示CTEPH的发病机制,对于了解其发生和发展、开展相关的药物治疗研究和制定干预策略具有重要意义。现从动物模型的相关研究进展出发,就近年来国内外有关构建CTEPH实验动物模型的方法作简要的介绍和评价。Chronic thromboembolic pulmonary hypertension(CTEPH)is considered to be a long-term complication of acute pulmonary thromboembolism.However,studies have shown that some patients diagnosed with CTEPH have no history of symptomatic pulmonary thromboembolism,suggesting that pulmonary thromboembolism is not the sole cause of CTEPH.Despite the extensive progress in recent research on pulmonary hypertension,the lack of relevant studies on the pathophysiology of CTEPH leaves many challenges of comprehensive treatment for these patients and their prognosis remains poor.Thus,developing reasonable and reliable animal models to reveal the pathogenesis of CTEPH is critical for elucidating its development,conducting relevant drug therapy studies,and developing effective intervention strategies.Based on the progress of recent research,this article will give a brief introduction and evaluation of different CTEPH experimental animal models.

关 键 词：慢性血栓栓塞性肺动脉高压 动物模型 病理生理 肺动脉高压 

分 类 号：R54[医药卫生—心血管疾病]