孤独症谱系障碍儿童动作协调能力与运动区皮质静息功能连接的特征分析  

Characteristics Analysis of Coordination Ability and Resting State Functional Connectivity of Motor Area Cortex in Children with Autism Spectrum Disorder

作　　者：张亚茹 文世林[1] 张雪冬 李文意 陈功和 李雅 王子鑫 李倩倩 魏兵 ZHANG Yaru;WEN Shilin;ZHANG Xuedong;LI Wenyi;CHEN Gonghe;LI Ya;WANG Zixin;LI Qianqian;WEI Bing(Capital University of Physical Education and Sports,Beijing 100191,China;Beijing Jianxiang School,Beijing 100086,China)

机构地区：[1]首都体育学院,北京100191 [2]北京市健翔学校,北京100086

出　　处：《首都体育学院学报》2022年第2期170-179,共10页Journal of Capital University of Physical Education and Sports

基　　金：北京市社会科学基金项目(19YTB011)。

摘　　要：目的:明确孤独症谱系障碍(ASD)儿童动作协调能力与运动区皮质静息功能连接的关系。方法:共招募11名ASD儿童和20名典型发展儿童(TD)。应用儿童协调能力测量量表(M-ABC2)测试动作协调能力,用近红外光谱技术(fNIRS)监测运动区皮质静息态的血氧信号变化,并用“FC-NIRS”软件计算运动区皮质的静息功能连接(RSFC)强度。结果:ASD组的M-ABC2总分显著低于同龄的TD组[t_((n=29))=-11.550,p=0.000],且精细动作能力(U=0,Z=-4.561,p=0.000)、手眼协调能力[t_((n=29))=-10.204,p=0.000]及静态和动态平衡能力[t_((n=29))=-5.752,p=0.000]存在显著差异。ASD组的RSFC强度均值显著低于TD组[在HbO信号水平上,t_((n=29))=-3.740,p=0.001],且脑右侧运动区存在差异的功能连接“边”的数量多于左侧。M-ABC总分与运动区RSFC均值之间存在显著相关[在HbO信号水平上,r=0.497,p=0.004],但在M-ABC2各二级指标上均与RSFC无相关性。结论:孤独症谱系障碍儿童的动作协调能力和运动区静息功能连接强度的发展均滞后于同龄的典型发展儿童,但是动作协调能力的损伤不一定与运动区功能连接强度的减弱有关。Objective:To clarify the relationship between motor coordination ability and resting function of motor cortex in children with autism spectrum disorder(ASD).Methods:A total of 11 children with ASD and 20 typically developing(TD)children were recruited.First,the Movement Assessment Battery for Children-second edition(M-ABC2)Checklist was administered to assess the motor coordination ability.Second,changes in the motor area's blood oxygen signals in resting states were collected by functional near infrared spectroscopy(fNIRS).Finally,FC-NIRS software was used to calculate the Resting State Functional Connectivity(RSFC)of the cortical motor area.Results:the total scores of the M-ABC2 of the ASD children were significant lower than the age-matched TD children(t_((n=29))=-11.550,p=0.000),and the differences were also significant in fine hands motor ability(U=0,Z=-4.561,p=0.000),hand-eye coordination ability(t_((n=29))=-10.204,p=0.000),and static and dynamic balance ability(t_((n=29))=-5.752,p=0.000).The mean value of the RSFC strength of ASD children was significant lower than the control group(at the HbO signals level,t_((n=29))=-3.740,p=0.001)as well as numbers of the“edges”of the RSFC in the right motor area of the brain were greater than the left.Though there was a significant correlation between the total score of the M-ABC2 and the mean value of the RSFC strength(at the HbO signals level,r=0.497,p=0.004)within all subjects,no significant correlation was found at each group.Conclusions:Both the development of the motor coordination ability and the RSFC of the motor area of the ASD children lagged far behind the age-matched TD children,and the impairment in the motor coordination ability had no relationships to the decrease of the RSFC of the motor area.

关 键 词：孤独症谱系障碍 动作协调能力 运动区皮质 静息功能连接 近红外光谱技术 

分 类 号：G804.55[文化科学—运动人体科学]