“Life is short,and art is long”:RNA degradation in cyanobacteria and model bacteria  

作　　者：Ju-Yuan Zhang Wolfgang R.Hess Cheng-Cai Zhang 

机构地区：[1]State Key Laboratory of Freshwater Ecology and Biotechnology and Key Laboratory of Algal Biology,Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan,China [2]Genetics and Experimental Bioinformatics,Faculty of Biology,University of Freiburg,Freiburg,Germany [3]Institut WUT-AMU,Aix-Marseille University and Wuhan University of Technology,Wuhan,China

出　　处：《mLife》2022年第1期21-39,共19页微生物（英文）

基　　金：supported by the National Natural Science Foundation of China(grant No.32070037);the Featured Institute Service Project from the Institute of Hydrobiology,the Chinese Academy of Sciences(grant No.Y85Z061601);the German Science Foundation(DFG)research training group BioInMe 322977937/GRK2344 and grant HE 2544/14-2(to Wolfgang R.Hess).

摘　　要：RNA turnover plays critical roles in the regulation of gene expression and allows cells to respond rapidly to environmental changes.In bacteria,the mechanisms of RNA turnover have been extensively studied in the models Escherichia coli and Bacillus subtilis,but not much is known in other bacteria.Cyanobacteria are a diverse group of photosynthetic organisms that have great potential for the sustainable production of valuable products using CO_(2)and solar energy.A better understanding of the regulation of RNA decay is important for both basic and applied studies of cyanobacteria.Genomic analysis shows that cyanobacteria have more than 10 ribonucleases and related proteins in common with E.coli and B.subtilis,and only a limited number of them have been experimentally investigated.In this review,we summarize the current knowledge about these RNAturnover-related proteins in cyanobacteria.Although many of them are biochemically similar to their counterparts in E.coli and B.subtilis,they appear to have distinct cellular functions,suggesting a different mechanism of RNA turnover regulation in cyanobacteria.The identification of new players involved in the regulation of RNA turnover and the elucidation of their biological functions are among the future challenges in this field.

关 键 词：CYANOBACTERIA RNA maturation RNA metabolism RNA turnover RIBONUCLEASES 

分 类 号：Q93[生物学—微生物学]