加倍剂量替加环素治疗呼吸机相关性肺炎的临床效果  

Clinical effect of doubled dose tigecycline in the treatment of ventilator-associated pneumonia

作　　者：张胜睿[1] 朱运林[1] 朱建龙 匡智明 ZHANG Sheng-rui;ZHU Yun-lin;ZHU Jian-long;KUANG Zhi-ming(Department of Critical Care Medicine,Ganzhou People's Hospital,Ganzhou City,Jiangxi Province,341000,China)

机构地区：[1]赣州市人民医院重症医学科,江西赣州341000

出　　处：《蛇志》2022年第1期38-40,47,共4页Journal of Snake

摘　　要：目的探讨加倍剂量替加环素治疗呼吸机相关性肺炎的临床效果。方法选择2020年2月~2021年8月我院治疗的呼吸机相关性肺炎患者100例,按照随机数字表法分为对照组和观察组各50例。对照组严格按照说明书使用替加环素(首剂量为100 mg,然后每间隔12 h静脉滴注50 mg)治疗,观察组则使用加倍剂量替加环素(首剂量为100 mg,然后每间隔12 h静脉滴注100 mg)治疗,观察比较两组患者的发热时间、肺部啰音及住院时间、使用抗菌药物时间等指标,以及治疗前后炎症因子hs-CRP水平的变化,并统计肺部细菌清除率及治疗期间并发症发生情况。结果观察组的发热持续时间、肺部啰音持续时间、住院时间及使用抗菌药物时间均显著短于对照组,差异均有统计学意义(均P<0.05)。两组患者治疗后的hs-CRP水平均低于治疗前,且观察组治疗后的hs-CRP水平明显低于对照组,差异均有统计学意义(均P<0.05)。治疗1疗程后,观察组的肺部细菌清除率显著高于对照组(P<0.05),而两组治疗期间的并发症发生率比较差异无统计学意义(P>0.05)。结论加倍剂量替加环素治疗呼吸机相关性肺炎的临床效果确切,能明显改善患者的临床症状,降低机体炎症反应,且并发症少,具有临床应用价值。Objective To explore the clinical effect of doubled dose tigecycline in the treatment of ventilator-associated pneumonia.Methods 100 cases of ventilator-associated pneumonia were admitted to our hospital from February 2020 to August 2021 who developed ventilator-associated pneumonia after being treated with a ventilator were selected as the research objects.According to the random number table method,they were divided into two groups,each with 50 cases.The control group was used strictly in accordance with the instructions.The first dose was 100 mg,followed by intravenous infusion of 50 mg every 12 hours.The observation group was given a doubled dose of tigecycline,the first dose was 100 mg,followed by 100 mg intravenous infusion every 12 hours.Note,compare the two groups of indicators such as fever,pulmonary rales,hospitalization and use of antimicrobial drugs,compare the changes in the levels of the inflammatory factor hs-CRP before and after treatment in the two groups,and count the lung bacterial clearance rates and occurrences during treatment in the two groups after 1 course of treatment Complications.Results The duration of fever,the duration of lung rales,the length of hospitalization and the use of antibiotics in the observation group were significantly shorter than those in the control group(P<0.05 for each).The hs-CRP levels in the observation group after treatment were lower than those before and after treatment Group(P<0.05 for both).The lung bacteria clearance rate in the observation group was significantly higher than that in the control group after 1 course of treatment(P<0.05).Comparison of the total proportions of loss of appetite,liver damage,renal damage and abnormal blood coagulation in the two groups the difference was not statistically significant(P>0.05).Conclusion The double-dose tigecycline treatment of ventilator-associated pneumonia has a reliable clinical effect,effectively reduces the body's inflammatory response,ensures the clearance of pulmonary bacteria,and has a reliable effect o

关 键 词：加倍剂量 替加环素 呼吸机相关性肺炎 肺部细菌清除率 并发症 

分 类 号：R563.1[医药卫生—呼吸系统]