贵州省少数民族与汉族人群心房颤动患者KCNE1(D85N)和KCNE4(E145D)基因单核苷酸多态性研究  

Study on KCNE1(D85N)and KCNE4(E145D)gene single nucleotide polymorphisms in patients with atrial fibrillation in Guizhou minorities and Han populations

作　　者：徐诗佳 李伟 吴立荣 周纬 陈林林 武哲以 段宗刚 罗振华[3,4] XU Shijia;LI Wei;WU Lirong;ZHOU Wei;CHEN Linlin;WU Zheyi;DUAN Zonggang;LUO Zhenhua(Department of Cardiovascular Medicine,Affiliated Hospital of Guizhou Medical University,Guiyang 550000,China;Department of Cardiovascular Medicine,Guiyang Second People's Hospital;Central Laboratory of Guizhou Provincial Peoples Hospital;Key Laboratory of Diagnosis and Treatment of Pulmonary Immune Diseases,National Health Commission)

机构地区：[1]贵州医科大学附属医院心血管内科,贵阳550000 [2]贵阳市第二人民医院心血管内科 [3]贵州省人民医院中心实验室 [4]国家卫生健康委员会肺脏免疫性疾病诊治重点实验室

出　　处：《临床心血管病杂志》2022年第2期151-157,共7页Journal of Clinical Cardiology

基　　金：国家自然科学基金(No:81960047、82160086);贵州省科技计划项目(No:黔科合支撑[2019]2800号);贵州省普通高等学校科技拔尖人才支撑计划(No:黔教合KY字[2016]070);贵阳市科技计划项目(No:筑科合同[2018]1-9);贵州省卫生健康委省级重点建设学科支持项目。

摘　　要：目的:探讨KCNE1(D85N)和KCNE4(E145D)基因单核苷酸多态性与贵州少数民族、汉族心房颤动(AF)发生的关联性。方法:收集贵州地区少数民族聚居地区AF患者185例作为病例组,健康成年人192例为对照组,检测各人群的KCNE1(D85N)和KCNE4(E145D)基因型、等位基因分布特点,结合临床资料分析各因素与AF的相关性。结果:AF与KCNE1(D85N)基因多态性无关(P>0.05),但与KCNE4(E145D)基因多态性有关(P<0.05),排除相关影响因素行logistic回归分析发现,KCNE4(E145D)基因多态性与贵州少数民族AF发生有显著关联,携带GG基因型可能是贵州少数民族人群发生AF的危险因素,而携带TT基因型可能是贵州少数民族和汉族人群发生AF的保护因素。结论:贵州地区少数民族和汉族AF发生可能与KCNE4(E145D)基因多态性有关。Objective:To investigate the association between single nucleic acid polymorphism of KCNE1(D85 N)and KCNE4(E145 D)genes and atrial fibrillation in Guizhou ethnic minority and Han nationality.Methods:A total of 185 patients with atrial fibrillation were selected as the case group and 192 healthy adults as the control group in Guizhou ethnic minority areas.In each population,genotypes and alleles of KCNE1(D85 N)and KCNE4(E145 D)were detected.The correlation between each factor and atrial fibrillation was analyzed.Results:Atrial fibrillation was not associated with KCNE1(D85 N)gene polymorphism(P>0.05),but was associated with KCNE4(E145 D)gene polymorphism(P<0.05).Logistic regression analysis showed that KCNE4(E145 D)gene polymorphism was significantly associated with the occurrence of atrial fibrillation in Guizhou ethnic groups,and GG genotype may be a risk factor.TT genotype may be a protective factor.Conclusion:KCNE4(E145 D)gene polymorphism may be associated with atrial fibrillation in Guizhou ethnic minority and Han nationality.

关 键 词：心房颤动 KCNE1(D85N) KCNE4(E145D) 基因单核苷酸多态性 

分 类 号：R541.7[医药卫生—心血管疾病]