重视配型新技术 推进精准肾移植  

Utilizing modern tissue typing technologies to promote precision kidney transplantation

作　　者：张雷 郑瑾[2] 薛武军[3] Zhang Lei;Zheng Jin;Xue Wujun(Department of Organ Transplantation,Changhai Hospital,Naval Medical University,Shanghai 200433,China;Institute of Organ Transplantation,Xi′an Jiaotong University,Xi′an 710061,China;Department of Renal Transplantation,Hospital of Nephrology,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710061,China)

机构地区：[1]海军军医大学附属长海医院器官移植科,上海200433 [2]西安交通大学器官移植研究所,西安710061 [3]西安交通大学第一附属医院肾病医院肾移植科,西安710061

出　　处：《中华医学杂志》2022年第10期683-686,共4页National Medical Journal of China

基　　金：国家自然科学基金(82170768);上海长海医院“234学科攀峰计划”(2019YXK002)。

摘　　要：提升质量是目前我国肾移植的主要发展目标。推广组织配型新技术,包括采用高分辨人类白细胞抗原(HLA)分型方法,保证供受者HLA分型结果的完整性和唯一性,以及把改良的细胞学方法和纯化单抗原技术相结合,提高HLA抗体检测精准度等,可以更准确地评估供受者间的错配负荷和受者免疫风险,指导器官的科学分配和受者个体化免疫抑制治疗,有助于达到受者长期存活的目标。这正是精准医学的核心要义在肾移植领域的体现。Improving quality is the primary goal of the kidney transplantation community in China.Promoting new technologies for tissue typing,including adopting high-resolution human leucocyte antigen(HLA)typing methods to ensure the integrity and uniqueness of the donor and recipient HLA genotype,combining modified cytological method and purified single antigen technology to improve the accuracy of HLA antibody detection,etc.,can assess the donor-recipient′s mismatch load and the immune risk of recipients more precisely,so as to guide the scientific allocation of organs and individualized immunosuppressive regime,which can contribute to the long-term survival of recipients.This is the embodiment of the core essence of"precision medicine"in the field of kidney transplantation.

关 键 词：肾移植 组织配型 器官分配 个体化免疫抑制治疗 

分 类 号：R699.2[医药卫生—泌尿科学]