替加环素致肾移植术后患者急性胰腺炎  

Acute pancreatitis induced by tigecycline in a patient after renal transplantation

作　　者：刘东华[1] 邢晓敏[1] 杨雪[1] 梁瑜[1] 赵俊[1] 刘雪莲 于静[1] 刘月芬[1] Liu Donghua;Xing Xiaomin;Yang Xue;Liang Yu;Zhao Jun;Liu Xuelian;Yu Jing;Liu Yuefen(Department of Pharmacy,the Affiliated Hospital of Qingdao University,Shandong Province,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院药学部,青岛266000

出　　处：《药物不良反应杂志》2022年第3期155-157,共3页Adverse Drug Reactions Journal

摘　　要：1例25岁男性肾移植术后患者因供肾保存液细菌培养结果为耐碳青霉烯鲍曼不动杆菌,术后第3天加用替加环素50 mg静脉滴注、1次/12 h。使用替加环素第4天,患者出现上腹部疼痛,予护胃治疗后好转;第8天,患者左下腹出现持续性剧痛;第9天,实验室检查示淀粉酶1188 U/L、脂肪酶699 U/L;胰腺超声检查示急性水肿性胰腺炎。诊断为急性胰腺炎,考虑与替加环素有关。停用该药,予醋酸奥曲肽注射液0.6 mg入0.9%氯化钠注射液50 ml静脉滴注、2次/d,同时禁饮食。5 d后,患者腹痛症状明显好转,胰淀粉酶下降至69 U/L,脂肪酶下降至646 U/L。A 25‑year‑old male patient received intravenous infusion of tegacyclin 50 mg once per 12 hours from the 3rd day after renal transplantation because the bacterial culture of the donor kidney preservation solution showed carbapenem resistant Acinetobacter baumannii.On the 4th day after using tegacyclin,the patient developed epigastric pain,which was improved after gastric protection treatment.On the 8th day of medication,the patient developed persistent severe pain in his left lower abdomen.On the 9th day of medication,laboratory tests showed amylase 1188 U/L and lipase 699 U/L.Pancreatic ultrasonic examination suggested acute edematous pancreatitis.Acute pancreatitis was diagnosed,which was considered to be related to tigecycline.Tigecycline was stopped.An IV infusion of octreotide acetate injection 0.6 mg dissolved in 0.9%sodium chloride injection 50 ml twice daily was given and diet was prohibited at the same time.Five days later,his symptoms of abdominal pain was improved significantly,pancreatic amylase decreased to 69 U/L,and lipase decreased to 646 U/L.

关 键 词：肾移植 胰腺炎 替加环素 

分 类 号：R969[医药卫生—药理学]