槐杞黄颗粒对毛细支气管炎后气道炎症的干预作用  

Effects of Huaiqihuang Granules on airway inflammation in bronchiolitis

作　　者：郝珉 李媛媛 宋文 杨美 赵明 路苓 Hao Min;Li Yuanyuan;Song Wen;Yang Mei;Zhao Ming;Lu Ling(Department of Pediatrics,Zaozhuang Municipal Hospital,Jining Medical University,Zaozhuang 277100,Shandong Province,China;Department of Pediatrics,Yicheng Hospital of Traditional Chinese Medicine,Zaozhuang 277100,Shandong Province,China)

机构地区：[1]济宁医学院附属枣庄市立医院儿科,枣庄277100 [2]枣庄市峄城区中医院儿科,枣庄277100

出　　处：《中国基层医药》2022年第4期486-489,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：济宁医学院教师科研扶持基金(JYFC2019FKJ101)。

摘　　要：目的观察槐杞黄颗粒对毛细支气管炎后气道炎症炎性因子及再喘息发生的干预效果。方法选取枣庄市立医院和峄城区中医院2018年1月至2019年10月收治的患儿120例为研究对象,采用随机数字表法分为实验组和对照组各60例。患儿均予常规治疗,实验组患儿加用槐杞黄颗粒口服。所有患儿分别于入院时和出院2个月时检测肺功能和血清、尿炎性因子,发病后3个月和1年电话随访统计患儿再喘息的发生情况。结果两组患儿肺功能比较,实验组患儿较对照组患儿达峰容积比(TPTEF/TE)、达峰时间比(VPTEF/VE)显著升高(t=3.13、3.60,均P<0.01),而潮气峰流量与呼出25%潮气量时呼气流量比(PF/TEF25)、公斤功能残气量(FRCp/kg)显著降低(t=3.88、3.74,均P<0.01)。两组患儿炎性因子比较,实验组患儿较对照组患儿白细胞介素4(IL-4)、γ-干扰素(IL-4/IFN-γ)显著降低(t=5.70、8.93,均P<0.01),而IFN-γ显著升高(t=3.85,P<0.01)。两组患儿治疗后尿白三烯E4(LTE-4)差异无统计学意义(t=1.18,P>0.05)。实验组患儿3个月内喘息再次发作例数和1年内喘息发作≥3次例数均显著少于对照组(χ^(2)=5.18、6.98,P<0.01或0.05)。结论槐杞黄颗粒可以有效调节Th1/Th2比例平衡,抑制毛细支气管炎后气道炎症,改善肺功能,减少再喘息的发生。Objective To investigate the effects of Huaiqihuang Granule on airway inflammation and wheezing reattack in bronchiolitis.Methods A total of 120 patients with bronchiolitis presenting airway inflammation and wheezing reattack who received treatment in Zaozhuang Municipal Hospital and Yicheng Hospital of Traditional Chinese Medicine between January 2018 and October 2019 were included in this study.These patients randomly underwent either conventional treatment(control group,n=60)or conventional treatment+Huaiqihuang Granule treatment(experimental group,n=60).They received pulmonary function examinations and laboratory tests for evaluating serum and urinary inflammatory factors at admission and 2 months after discharge.They were followed up by telephone 3 months and 1 year after onset.Results The ratio of time to reach the peak tidal expiratory flow over total expiratory time(TPTEF/TE)and the volume to peak tidal expiratory flow to total expiratory volume(VPTEF/VE)were significantly higher in the experimental group compared with those in the control group(t=3.13,3.60,all P<0.01).The ratio of tidal peak flow to tidal expiratory flow when 25%of tidal volume remains in the lungs(PF/TEF25)and functional residual capacity/kg(FRCp/kg)significantly decreased in the experimental group compared with those in the control group(t=3.88,3.74,all P<0.01).Interleukin-4 level and the ratio of interleukin-4/γ-interferon levels were significantly lower in the experimental group than in the control group(t=5.70,8.93,all P<0.01).Gamma-interferon level was significantly higher in the experimental group than in the control group(t=3.85,P<0.01).There was no significant difference in urinary leukotriene E4 level post-treatment between the two groups(t=1.18,P>0.05).The number of patients who had a wheezing attack again within 3 months post-treatment and the number of patients who had≥3 wheezing attacks were significantly lower in the experimental group compared with those in the control group(χ^(2)=5.18,6.98,P<0.01 or 0.05).Conclusion

关 键 词：槐杞黄颗粒 毛细支气管炎 气道炎症 肺功能 喘息 

分 类 号：R272[医药卫生—中医儿科学]