高毒力肺炎克雷伯菌的研究进展  

Research progress of highly virulent Klebsiella pneumoniae

作　　者：曹身云 李震(综述)[1] 赵书平(审校)[1] CAO Shenyun;LI Zhen;ZHAO Shuping(Department of Clinical Laboratory,Central Hospital of Tai′an City,Tai′an,Shandong 271000,China)

机构地区：[1]山东省泰安市中心医院检验科,山东泰安271000

出　　处：《国际检验医学杂志》2022年第7期864-868,共5页International Journal of Laboratory Medicine

基　　金：山东省自然科学基金(ZR2016HL44);山东省保健科技协会科学技术课题(SDBJKT20180033)。

摘　　要：高毒力肺炎克雷伯菌(hvKP)致病性强,导致的感染多以严重的原发性肝脓肿为首发症状,并可合并眼内炎、败血症等其他部位的迁徙性感染。虽然传统观点认为hvKP对抗菌药物敏感性高。但近年来陆续发现了对多种药物耐药的hvKP菌株,高毒力与高耐药的重叠给临床治疗带来了极大挑战。本文对hvKP的流行现状、毒力影响因素及耐药性方面的研究现状进行综述,以期为hvKP的预防和治疗提供理论依据。Hypervirulent Klebsiella pneumoniae(hvKP)is highly pathogenic,resulting in severe primary liver abscess as the first symptom,and migratory infection in other sites such as endophthalmitis and sepsis.Although hvKP is traditionally considered to be highly sensitive to multiple drugs.However,in recent years,multiple drug-resistant strains of HVKP have been successively discovered.The overlap of high virulence and high drug resistance has brought great challenges to clinical treatment.In this paper,the prevalence,virulence factors and drug resistance of hvKP were reviewed in order to provide theoretical basis for the prevention and treatment of hvKP.

关 键 词：高毒力肺炎克雷伯菌 毒力影响因素 耐药性 

分 类 号：R446.5[医药卫生—诊断学]