可降解Gel-MA水凝胶双光子聚合加工技术研究  

Study on Processing Parameters of Degradable Gel-MA Hydrogel for Two-photon Polymerization

作　　者：于保军[1] 董金博 靖贤 林洁琼[1] YU Baojun;DONG Jinbo;JING Xian;LIN Jieqiong(School of Mechanical Engineering,Changchun University of Technology,Changchun 130012,China)

机构地区：[1]长春工业大学机电工程学院,吉林长春130012

出　　处：《电加工与模具》2022年第S01期46-48,53,共4页Electromachining & Mould

基　　金：吉林省自然科学基金项目(20190103061JH)。

摘　　要：可降解甲基丙烯酰胺改性明胶(Gel-MA)具有良好的生物兼容性和可降解性,被广泛应用于生物支架、药物输送载体和软骨替代物等方面,在生物医疗领域具有极大的应用前景。分别将Gel-MA和苯基-2,4,6-三甲基苯甲酰基亚磷酸锂(LAP)作为单体和光引发剂,合成了一种具有生物兼容性的可降解光刻胶,并改进了双光子聚合加工过程中的工艺流程,研究了激光功率和扫描速度对聚合线宽的影响关系,实现了80μm×80μm×20μm微型生物支架的双光子聚合加工,为双光子聚合加工生物兼容性可降解材料提供参考。Degradable gelatin methacryloyl(Gel-MA)has a good biocompatibility and degradability to be widely used in biological scaffolds,drug delivery carriers and cartilage substitutes,and has great application prospects in biomedical treatment.Using Gel-MA and phenyl-2,4,6-trimethylbenzoyl lithium phosphite(LAP)as monomers and photoinitiators,a biocompatible degradable photoresist was synthesized,and the process flow during two-photon polymerization processing was improved.The influence of laser power and scanning speed on the polymerization line width was studied,and the two-photon polymerization processing of 80μm×80μm×20μm micro-biological scaffolds was realized,which provides a reference for the two-photon polymerization processing of biocompatible and degradable materials.

关 键 词：双光子聚合 激光微细加工 水凝胶 

分 类 号：TG665[金属学及工艺—金属切削加工及机床]