系统性红斑狼疮患者血清IL-1家族多种细胞因子、拮抗剂及可溶性受体水平表达与疾病活动度的相关性研究  

Correlation between Serum IL-1 Family Cytokines,Antagonists and Soluble Receptors and Disease Activity in Patients with Systemic Lupus Erythematosus

作　　者：张帮林[1] 郑琳 罗婷 ZHANG Bang-lin;ZHENG Lin;LUO Ting(Department of Clinical Laboratory,Luzhou Traditional Chinese Medicine Hospital,Sichuan Luzhou 646000,China)

机构地区：[1]泸州市中医医院检验科,四川泸州646000

出　　处：《现代检验医学杂志》2022年第2期88-92,共5页Journal of Modern Laboratory Medicine

基　　金：四川省卫生和计划生育委员会科研课题(17PJ302)。

摘　　要：目的 分析系统性红斑狼疮(systemic lupus erythematosus,SLE)病人血清中IL-1家族细胞因子、拮抗剂与可溶性受体含量变化与临床价值。方法 选取泸州市中医医院于2018年6月~2020年6月期间收治的60例SLE病人为观察组,同期60例健康体检人员为对照组,另基于SLE疾病活动指数评分(SLEDAI),划分观察组为活动组和稳定组。对比上述三组IL-1家族细胞因子、拮抗剂、可溶性受体含量,并对SLE患者细胞因子水平与免疫指标ds-DNA,补体C3,C4,C1q的相关性进行分析。结果 观察组与对照组比较,细胞因子IL-33[1.5(0~2.90) vs 0.2(0~1.46)]pg/ml,IL-18[329.2(271.5~386.2) vs 430.0(314.6~587.8)]pg/ml,拮抗剂IL-18BP[6 455(5 021~8 357) vs 9 863(6 982~15 746)]pg/ml,IL-1Ra[173.5(120.3~213.8)vs226.9(129.9~478.2)]pg/ml和可溶性受体IL-1R4[1004(7356~12 553)vs 15 870(12336~23 569)]pg/ml差异均有统计学意义(t=7.446,8.513,10.256,5.864,12.257,均P<0.05)。SLE患者细胞因子IL-18,free IL-18,IL-1R2,IL-1R4与多项自身抗体或补体间存在相关性(r=-0.328~0.412,均P<0.05)。SLE活动组患者IL-18,free IL-18,IL-1R4细胞因子水平与稳定组患者间差异有统计学意义(均P<0.05)。结论 IL-18和IL-1R4可能为预测SLE患者疾病活动度的候选生物标志物。Objective To analyze the changes and clinical value of IL-1 family cytokines, antagonists and soluble receptors in systemic lupus erythematosus(SLE) patients. Methods Selected a total of 60 SLE patients treated in the Luzhou Traditional Chinese Medicine Hospital from June 2018 to June 2020 as the observation group, while subjects in the control group were 60 healthy physical examination personnel in the same period. In addition, based on SLEDAI, the observation group was divided into the active group and the inactive group. The contents of IL-1 family cytokines, antagonists and soluble receptors in the above three groups were compared, and the correlation between the levels of cytokines in SLE patients and immune indexes ds-DNA, complement C3, C4 and C1 q was analyzed. Results There were significant differences in cytokines IL-33[1.5(0~2.90) vs 0.2(0~1.46)]pg/ml, IL-18[329.2(271.5~386.2) vs 430.0(314.6~587.8)]pg/ml, antagonists IL-18 BP[6 455(5 021~8 357) vs 9 863(6 982~15 746)]pg/ml, IL-1 Ra[173.5(120.3~213.8) vs 226.9(129.9~ 478.2)]pg/ml and soluble receptor IL-1 R4[1 004(7 356~12 553) vs 15 870(12 336 ~ 23 569)]pg/ml between the observation group and the control group(t = 7.446,8.513,10.256,5.864,12.257, all P < 0.05). There was a correlation between cytokines IL-18, freeIL-18, IL-1 R2, IL-1 R4 and multiple autoantibodies or complements in SLE patients(r=-0.328~0.412,all P < 0.05). The levels of IL-18, free IL-18 and IL-1 R4 cytokines in SLE active group were significantly higher than those in stable group(all P < 0.05). Conclusion IL-18 and IL-1 R4 may be candidate biomarkers for predicting disease activity in SLE patients.

关 键 词：系统性红斑狼疮 IL-1家族细胞因子 疾病活动度 

分 类 号：R593.241[医药卫生—内科学] R392.11[医药卫生—临床医学]