慢性HBV感染者血清持续低水平HBsAg表达免疫耐受机制的研究进展  

Research Progress on Immune Tolerance Mechanism of Persistent Low-level Serum HBsAg Expression in Patients with Chronic HBV Infection

作　　者：吴婕 张英杰 周华君 成军 WU Jie;ZHANG Ying-jie;ZHOU Hua-jun;CHENG Jun(School of Laboratory Medicine,Bengbu Medical College,Anhui Bengbu 233000,China;Department of Clinical Research,the 903rd Hospital of PLA,Hangzhou 310013,China)

机构地区：[1]蚌埠医学院检验医学院,安徽蚌埠233000 [2]中国人民解放军联勤保障部队第九〇三医院,杭州310013

出　　处：《现代检验医学杂志》2022年第2期199-204,共6页Journal of Modern Laboratory Medicine

基　　金：浙江省自然科学基金(LY15H 200001)。

摘　　要：乙型肝炎是一种常见的感染性疾病,乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)是乙型肝炎病毒(hepatitis B virus,HBV)感染的重要血清标志物之一。慢性HBV感染者血清持续低水平HBsAg表达是在多种因素的综合作用下,HBV自身复制与宿主免疫清除达到一种相对稳定而复杂的动态平衡状态,其HBV DNA呈现低复制,因此,HBV感染者血清持续低水平HBsAg状态下仍具有潜在传染风险性,已受到了传染病学、流行病学等领域专家的广泛关注。目前,有关血清持续低水平HBsAg表达的形成机制尚不完全明确,但持续低水平HBsAg表达形成机制中存在着宿主免疫耐受现象被广大学者所认可,然而如何打破宿主对持续低水平HBsAg表达的免疫耐受,实现宿主对病毒的清除是现阶段面临的严峻挑战,为此该文对慢性HBV感染者血清持续低水平HBsAg表达免疫耐受机制的相关研究进展进行综述,为打破免疫耐受、有效清除低水平HBV提供新思路。Hepatitis B is a common infectious disease, and hepatitis B surface antigen(HBsAg) is one of the important serum markers of hepatitis B virus(HBV) infection. The persistent low level of HBsAg expression in the serum of chronic HBV infected persons is a relatively stable and complex dynamic equilibrium state between HBV self-replication and host immune clearance under the comprehensive action of various factors, and its HBV DNA presents low replication. Therefore, the persistent low level of HBsAg in the serum of HBV infect persons still has potential infectious risk, which has been subject to infectious diseases extensive attention of experts in epidemiology and other fields. At present, the formation mechanism of sustained low-level HBsAg expression in serum is not completely clear, but the phenomenon of host immune tolerance in the formation mechanism of sustained low-level HBsAg expression is recognized by the majority of scholars. However, how to break the host’s immune tolerance to sustained low-level HBsAg expression and realize the host’s clearance of virus is a major challenge at this stage, therefore, this paper reviews the relevant research progress on the immune tolerance mechanism of persistent lowlevel HBsAg expression in patients with chronic HBV infection, so as to provide a new idea for breaking immune tolerance and effectively clearing low-level HBV.

关 键 词：乙型肝炎表面抗原 持续低水平表达 免疫耐受 

分 类 号：R512.62[医药卫生—内科学] R392.11[医药卫生—临床医学]