雷公藤多苷联合醋酸泼尼松和环磷酰胺冲击疗法对肾病综合征患者微炎症状态、NF-κB水平及ANGPTL3的影响  

Effects of tripterygium glycosides combined with prednisone acetate and cyclophosphamide pulse therapy on microinflammatory state,NF-κB level and ANGPTL3 in patients with nephrotic syndrome

作　　者：赵阿丽 吕琴 ZHAO Ali;LYU Qin(the First People's Hospital of Xianyang,Xianyang 712000;Xianyang Central Hospital,Xianyang 712000,China)

机构地区：[1]咸阳市第一人民医院,陕西咸阳712000 [2]咸阳市中心医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2022年第11期35-38,共4页Clinical Research and Practice

摘　　要：目的探讨雷公藤多苷联合醋酸泼尼松和环磷酰胺冲击疗法治疗肾病综合征的效果。方法选取2018年6月至2020年6月收治的76例肾病综合征患者为研究对象,以随机数字表法将其分为对照组和观察组,各38例。对照组采用醋酸泼尼松和环磷酰胺冲击疗法治疗,观察组在对照组基础上联合雷公藤多苷治疗。比较两组患者的临床疗效。结果观察组的治疗总有效率为94.74%,显著高于对照组的76.32%,差异具有统计学意义(P<0.05);治疗后,观察组的Scr、BUN水平及24 h Upro均显著低于对照组,差异具有统计学意义(P<0.05);治疗后,观察组的hs-CRP、TNF-α水平均显著低于对照组,差异具有统计学意义(P<0.05);治疗后,观察组的PT、APTT显著长于对照组,Fbg水平显著低于对照组,差异具有统计学意义(P<0.05);治疗后,观察组的NF-κB、ANGPTL3水平均显著低于对照组,差异具有统计学意义(P<0.05);两组的不良反应总发生率无明显差异(P>0.05)。结论雷公藤多苷联合醋酸泼尼松和环磷酰胺冲击疗法治疗肾病综合征的效果显著,可改善患者的凝血功能、微炎症状态,降低NF-κB、ANGPTL3水平,且不会增加不良反应,值得推广应用。Objective To explore the effect of tripterygium glycosides combined with prednisone acetate and cyclophosphamide pulse therapy in the treatment of nephrotic syndrome.Methods A total of 76 patients with nephrotic syndrome admitted from June 2018 to June 2020 were selected as the study objects and divided into control group and observation group by random number table method,with 38 cases in each group.The control group was treated with prednisone acetate and cyclophosphamide pulse therapy,and the observation group was treated with tripterygium glycosides on the basis of the control group.The clinical efficacy of the two groups were compared.Results The total effective rate of treatment in the observation group was 94.74%,which was significantly higher than 76.32%in the control group,the difference was statistically significant(P<0.05);after treatment,the levels of Scr,BUN and 24 h Upro in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05);after treatment,the levels of hs-CRP and TNF-αin the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05);after treatment,PT and APTT in the observation group were significantly longer than those in the control group,Fbg level was significantly lower than that in the control group,and the differences were statistically significant(P<0.05);after treatment,levels of NF-κB and ANGPTL3 in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05);there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Tripterygium glycosides combined with prednisone acetate and cyclophosphamide pulse therapy has a significant effect in the treatment of nephrotic syndrome,it can improve the coagulation function,microinflammatory state,reduce the NF-κB and ANGPTL3 levels,without increasing ad

关 键 词：醋酸泼尼松 环磷酰胺冲击疗法 雷公藤多苷 肾病综合征 微炎症状态 

分 类 号：R692[医药卫生—泌尿科学]