N-myc下游调控基因1在呼吸系统疾病中的研究进展  

Research progress on the role of N-myc downstream regulatory gene 1 in respiratory diseases

作　　者：李成伟 李圣青[1] LI Cheng-wei;LI Sheng-qing(Department of Pulmonary and Critical Care Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院呼吸与危重症医学科,上海200040

出　　处：《复旦学报（医学版）》2022年第2期282-288,共7页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金(81970048)。

摘　　要：N-myc下游调控基因1(N-myc downstream regulated gene-1,NDRG1)是NDRG家族的第一个成员,与低氧和应激相关。NDRG1广泛分布在全身多种组织器官中,具有特有的分子结构和化学修饰。在肺中NDRG1主要表达在呼吸道组织内,其表达水平和化学修饰与多种呼吸系统疾病的发生发展有密切关系,包括感染性疾病、慢性气道炎性疾病、低氧相关疾病(如肺损伤、急性呼吸窘迫综合征)等,同时在肿瘤低氧微环境、肿瘤进展及耐药等方面也发挥重要作用。本文就NDRG1在呼吸系统疾病中的相关研究进展作一综述。N-myc downstream regulated gene-1(NDRG1),the firstly identified member of NDRG family,is a hypoxia and stress related gene.NDRG1 is widely distributed and expressed in a variety of tissues and organs,with its unique molecular structure and chemical modification.NDRG1 is mainly expressed in the respiratory tract tissue in the lung.The expression level and chemical modification of NDRG1 is closely related to the occurrence and development of various respiratory diseases,including infectious diseases,chronic airway inflammatory diseases,hypoxia related diseases such as lung injury and acute respiratory distress syndrome,as well as hypoxic tumor microenvironment,tumor progression and therapeutic resistance.Therefore,this review summarizes the research progress on the role of NDRG1 in respiratory diseases.

关 键 词：N-myc下游调控基因1(NDRG1) 呼吸系统疾病 信号通路 

分 类 号：R563.9[医药卫生—呼吸系统]