新四联疗法与“金三角”方案对HFrEF患者近远期疗效的影响分析  

Analysis of the Effect of New Quadruple Therapy and"Golden Triangle"Regimen on Short-term and Long-term Efficacy of HFrEF Patients

作　　者：田伟 王智彬 刘蕾[1] TIAN Wei;WANG Zhibin;LIU Lei(Department of Cardiology,Anyang People's Hospital,Anyang Henan,455000,China)

机构地区：[1]安阳市人民医院心血管内科,河南安阳455000

出　　处：《临床研究》2022年第1期64-67,共4页Clinical Research

摘　　要：目的分析新四联疗法与“金三角”方案对射血分数下降心力衰竭(HFrEF)患者近远期疗效的影响。方法选取安阳市人民医院心血管内科2019年6月至2020年6月收治的80例HFrEF患者为研究对象,采用随机数字表法分为两组各40例。对照组采取“金三角”方案治疗,观察组采取新四联疗法治疗,3个月后比较两组患者的心功能指标、不良反应发生率。随访15个月并统计心血管死亡率、再住院率。结果治疗前两组患者的心功能指标比较,差异无统计学意义(P>0.05),治疗后均优于治疗前,且观察组优于对照组,差异有统计学意义(P<0.05);观察组患者的腹泻发生率5.00%、嗜睡发生率5.00%、皮疹发生率2.50%,与对照组的2.50%、2.50%、5.00%比较,差异无统计学意义(P>0.05);随访15个月,观察组心血管死亡率0.00%、再入院率5.00%,低于对照组的5.00%、15.00%,差异有统计学意义(P<0.05)。结论在HFrEF患者治疗中新四联疗法取得的近远期疗效优于“金三角”方案,可作为优选治疗方案加以推广使用。Objective To analyze the effect of new quadruple therapy and"Golden Triangle"regimen on the short-term and long-term efficacy of patients with heart failure with reduced ejection fraction(HFrEF).Methods A total of 80 patients with HFrEF admitted to the Department of Cardiovascular Medicine of Anyang People's Hospital from June 2019 to June 2020 were selected as the research objects,and divided into two groups with 40 cases in each group by random number table method.The control group was treated with the"Golden Triangle"regimen,and the observation group was treated with the new quadruple therapy.After 3 months,the cardiac function indexes and the incidence of adverse reactions were compared between the two groups.The patients were followed up for 15 months and the cardiovascular mortality and rehospitalization rate were calculated.Results There was no significant difference in the cardiac function indexes between the two groups before treatment(P>0.05),and after treatment was better than before treatment,and the observation group was better than the control group,the difference was statistically significant(P<0.05);The incidence of diarrhea in the observation group was 5.00%,the incidence of drowsiness was 5.00%,and the incidence of rash was 2.50%,compared with 2.50%,2.50%,and 5.00% in the control group,and there was no significant difference(P>0.05).Following up for 15 months,the cardiovascular mortality rate was 0.00% and the readmission rate was 5.00%in the observation group,which were lower than 5.00% and 15.00% in the control group,and the difference was statistically significant(P<0.05).Conclusion The short-term and long-term efficacy of the new quadruple therapy in the treatment of HFrEF patients is better than that of the"Golden Triangle"regimen,and it can be promoted and used as a preferred treatment regimen.

关 键 词：射血分数下降心力衰竭 新四联疗法 “金三角”方案 近远期疗效 

分 类 号：R714.252[医药卫生—妇产科学]