变应性鼻炎小气道病变的初步研究  

Effect of small airway disease on lower airway inflammation in patients with allergic rhinitis

作　　者：张恺 杨旭东[1] 陆汉强[1] Zhang Kai;Yang Xudong;Lu Hanqiang(Department of Otorhinolaryngology Head and Neck Surgery,Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu,212000,China)

机构地区：[1]江苏大学附属医院,江苏镇江212000

出　　处：《中国医学文摘（耳鼻咽喉科学）》2022年第2期60-62,共3页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的 初步探讨持续性变应性鼻炎(Persistent allergic rhinitis,PAR)小气道病变(Small airway disease,SAD)与嗜酸性粒细胞(Eosinophils,EOS)的关系;方法 PAR患者70例,依据SAD检测结果分为,A组:SAD异常组,B组:SAD正常组,以及C组:正常对照组,三组受试者均行诱导痰嗜酸性粒细胞(Eosinophils,EOS)检测;结果 在诱导痰EOS检测中,三组受试者组内差异均有统计学意义(P<0.05),且A组>B组>C组;结论 伴SAD的中-重度PAR患者表现出更严重的下气道EOS炎症,对此类患者的早期监测将有助于哮喘(Bronchial asthma,BA)的预防。Objective This article is an elementary discussion about the relationship between small airway disease and eosinophils in persistent allergic rhinitis;Method 70 patients with PAR were selected and separated on the basis of SAD, group A: abnormal SAD group, group B: normal SAD group, and group C: normal control group,all of them underwent induced sputum eosinophils tset. Results In the test of EOS in induced sputum, it exists significant differences among the three groups, A > B > C(P < 0.05). Conclusion Moderate-severe PAR patients with SAD show more severe EOS inflammation, and more attention should be paid to the evolution of asthma for such patients.

关 键 词：小气道病变 持续性变应性鼻炎 诱导痰EOS 

分 类 号：R56[医药卫生—呼吸系统]