异丙托溴铵联合醋酸泼尼松治疗慢性阻塞性肺气肿的临床效果  

Clinical Effect of Ipratropium Bromide Combined with Prednisone Acetate in the Treatment of Chronic Obstructive Pulmonary Emphysema

作　　者：赵惺奕 陈飞[2] ZHAO Xingyi;CHEN Fei(Department of Western Medicine,Nanyang First People's Hospital,Nanyang 473000,China;Department of Respiratory and Critical Care Medicine,Nanyang First People's Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院西药科,河南南阳473000 [2]南阳市第一人民医院呼吸与危重症医学一科,河南南阳473000

出　　处：《河南医学研究》2022年第6期1100-1103,共4页Henan Medical Research

摘　　要：目的探讨异丙托溴铵联合醋酸泼尼松治疗慢性阻塞性肺气肿的临床效果。方法选取南阳市第一人民医院2018年3月至2020年3月收治的102例慢性阻塞性肺气肿患者,依据随机数表法将患者分为两组,每组51例。对照组接受常规治疗联合异丙托溴铵雾化吸入治疗,观察组在对照组基础上加用醋酸泼尼松片治疗,两组均连续治疗1个月。比较两组治疗前、治疗1个月时肺功能、炎症因子水平、血气指标水平,比较两组治疗期间不良反应总发生率。结果治疗前,两组肺功能、炎症因子、血气指标水平相比,差异无统计学意义(P>0.05)。治疗1个月后,观察组第1秒用力呼气容积(FEV_(1))、最大呼气流量(PEF)水平较对照组高(P<0.05),血清降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)水平较对照组低(P<0.05),动脉血二氧化碳分压(PaCO_(2))较对照组低(P<0.05),动脉血氧分压(PaO_(2))较对照组高(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论异丙托溴铵联合醋酸泼尼松治疗慢性阻塞性肺气肿患者效果较好,可以有效改善患者的肺功能和血气指标,减轻炎症反应,且不会增加不良反应发生风险。Objective To investigate the clinical effect of ipratropium bromide combined with prednisone acetate in the treatment of chronic obstructive pulmonary emphysema.Methods A total of 102 patients with chronic obstructive pulmonary emphysema admitted to Nanyang First People's Hospital from March 2018 to March 2020 were selected,and the patients were divided into two groups according to the random number table method,with 51 cases in each group.The control group received conventional treatment combined with ipratropium bromide atomization inhalation therapy,and the observation group received prednisone acetate tablets on the basis of the control group.Both groups were treated for 1 month.The pulmonary function,inflammatory factor levels,and blood gas index levels were compared between the two groups before treatment and after 1 month of treatment,and the total incidence of adverse reactions during the treatment period was compared between the two groups.Results Before treatment,there were no statistical differences in the levels of lung function,inflammatory factors and blood gas indexes between the two groups(P>0.05).After 1 month of treatment,the levels of forced expiratory volume in one second(FEV_(1))and maximum expiratory flow(PEF)in the observation group were higher than those in the control group(P<0.05),the levels of serum procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)were lower than those of the control group(P<0.05),the patial pressure of carbon dioxide in arterial blood(PaCO_(2))was lower than that of the control group(P<0.05),and the partial pressure of oxygen in arterial blood(PaO_(2))was higher than that of the control group(P<0.05).There was no statistical difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Ipratropium bromide combined with prednisone acetate has a good effect in the treatment of patients with chronic obstructive pulmonary emphysema.It can effectively improve the pulmonary function and blood gas indexes of patients,reduce the inflamma

关 键 词：慢性阻塞性肺气肿 异丙托溴铵 醋酸泼尼松 肺功能 炎症因子 血气 

分 类 号：R563[医药卫生—呼吸系统]