南宁市0~3岁牛奶蛋白过敏症患儿生长发育研究及全程营养管理疗效观察  

Study on the growth and development of 0-3-year-old children with cow’s milk protein allergy and observation on the effect of whole-course nutrition management in Nanning

作　　者：陆俐先 王兆康 黄淑清 LU Lixian;WANG Zhaokang;HUANG Shuqing(Department of Pediatrics,the Eighth People’s Hospital of Nanning,Guangxi,Nanning 530001,China)

机构地区：[1]南宁市第八人民医院儿科,广西南宁530001

出　　处：《中国医药科学》2022年第6期73-77,共5页China Medicine And Pharmacy

基　　金：广西壮族自治区卫生健康委员会科研课题(计划课题)(Z20190286)。

摘　　要：目的探讨全程营养管理对儿童牛奶蛋白过敏症(CMPA)的疗效。方法选取2019年3月至2020年6月在南宁市第八人民医院等单位治疗的750例CMPA患儿为研究对象,随机分为研究1组和研究2组,每组各375例,选取同时期健康体检的非CMPA儿童600例为对照组。对照组正常喂养,研究2组按常规方法进行营养管理,研究1组由儿科营养医生全程指导,个体化补充维生素A、维生素D及锌等营养,观察三组生长发育情况及营养指标差异。结果干预前CMPA患儿身高、体重、维生素A、维生素D、锌、血清铁、视黄醇结合蛋白及IgG水平低于非CMPA儿童,而生长发育迟缓及营养不良发生率高于非CMPA儿童,差异有统计学意义(P<0.05)。干预后,研究1组CMPA患儿与健康儿童的身高、体重、维生素A、维生素D、锌、血清铁、视黄醇结合蛋白及IgG水平一致高于研究2组,血IgE、嗜酸细胞数低于研究2组,差异有统计学意义(P<0.05)。结论南宁市0~3岁CMPA患儿普遍存在营养不良、生长发育迟缓及维生素A、维生素D及锌缺乏现象,专业儿保医师全程营养管理可促进患儿生长发育。Objective To explore the effect of whole-course nutrition management on cow’s milk protein allergy(CMPA)in children.Methods A total of 750 children with CMPA in the Eighth People’s Hospital of Nanning and other institutions from March 2019 to June 2020 were selected as the research subjects.They were randomly divided into study group 1 and study group 2,with 375 cases in each group.600 non-CMPA children who underwent physical examination in the same period were taken as the control group.The control group was fed normally,the study group 2 received nutrition management according to conventional methods,and the study group 1 received the whole-course guidance of pediatric nutritionists and individualized supplement of vitamins A,D and zinc.The growth and development and nutritional indexes in the three groups were observed.Results Before the intervention,the height,body weight,levels of vitamins A,D,zinc,serum iron,retinol-binding protein and IgG in CMPA children were lower than those in non-CMPA children,while the incidence of growth retardation and malnutrition was higher than that in non-CMPA children,with statistically significant differences(P<0.05).After the intervention,the height,body weight,levels of vitamins A,D,zinc,serum iron,retinol-binding protein and IgG of CMPA children in the study group 1 were consistent with those of healthy children,but higher than those in the study group 2,and the levels of blood IgE and eosinophil counts were lower than those in the study group 2,with statistically significant differences(P<0.05).Conclusion Malnutrition,growth retardation and vitamins A,D and zinc deficiencies are common in 0-3-year-old children with CMPA in Nanning.The whole-course nutrition management by professional child-care physicians can promote the growth and development of affected children.

关 键 词：牛奶蛋白过敏症 生长发育 全程营养管理 0~3岁 

分 类 号：R722.1[医药卫生—儿科]