腹部局部理疗联合微生态制剂治疗对小儿腹泻的肠道菌群及免疫功能影响  

Effects of abdominal local physiotherapy combined with probiotics on intestinal flora and immune function in children with diarrhea

作　　者：王雨莎 陈观伟 陈康莲 梁巧玲 梁智 WANG Yusha;CHEN Guanwei;CHEN Kanglian;LIANG Qiaoling;LIANG Zhi(Zhanjiang Maternal and Child Health and Family Planning Service Center,Guangdong,Zhanjiang 524000,China)

机构地区：[1]广东省湛江市妇幼保健计划生育服务中心,广东湛江524000

出　　处：《中国医药科学》2022年第6期78-81,共4页China Medicine And Pharmacy

基　　金：广东省湛江市科技计划项目(2020B01334)。

摘　　要：目的探讨腹部局部理疗联合微生态制剂在小儿腹泻患儿中的疗效。方法选取2019年8月至2020年8月湛江市妇幼保健计划生育服务中心收治的96例小儿腹泻患儿,根据随机数字表法分成两组,每组各48例。对照组予以常规治疗^(+)双歧杆菌三联活菌治疗,观察组在此基础上加用腹部局部理疗治疗,连续治疗3 d。比较两组临床疗效、肠道菌群数量、免疫功能指标和不良反应发生情况。结果观察组治疗总有效率为95.83%,高于对照组的83.33%,差异有统计学意义(P<0.05);治疗前,两组乳酸杆菌、双歧杆菌、大肠埃希菌数量和免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、CD4^(+)/CD8^(+)水平比较,差异无统计学意义(P>0.05);治疗后,观察组乳酸杆菌、双歧杆菌数量多于对照组,大肠埃希菌数量少于对照组,IgA、IgG、CD4^(+)/CD8^(+)水平高于对照组,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论腹部局部理疗联合微生态制剂在小儿腹泻患儿治疗中效果确切,可纠正其肠道菌群紊乱状况,改善免疫功能,安全可靠,值得推广应用。Objective To investigate the efficacy of abdominal local physiotherapy combined with probiotics in children with diarrhea.Methods A total of 96 children with diarrhea treated in Zhanjiang Maternal and Child Health and Family Planning Service Center from August 2019 to August 2020 were selected and divided into two groups,with 48 cases in each group by the random number table method.The control group was given routine treatment and Bifidobacterium triple live bacteria,while the observation group was given abdominal local physiotherapy for 3 days on that basis.The clinical efficacy,the number of intestinal flora,immune function indexes and adverse reactions were compared between the two groups.Results The total effective rate of the observation group(95.83%)was higher than that of the control group(83.33%),with statistically significant difference(P<0.05).Before treatment,there were no statistically significant differences in the number of Lactobacillus,Bifidobacterium and Escherichia coli as well as the levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and CD4^(+)/CD8^(+)between the two groups(P>0.05).After treatment,the numbers of Lactobacillus and Bifidobacterium in the observation group were higher than those in the control group,the number of Escherichia coli was lower than that in the control group,and the levels of IgA,IgG and CD4^(+)/CD8^(+)were higher than those in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Abdominal local physiotherapy combined with probiotics is effective in the treatment of children with diarrhea and can correct the disorder of intestinal flora and improve immune function.It is safe,reliable and worthy of popularization and application.

关 键 词：小儿腹泻 腹部局部理疗 双歧杆菌三联活菌 肠道菌群 免疫功能 

分 类 号：R725.7[医药卫生—儿科]