CAP患者血清suPAR、syndecan-4水平与病情严重程度及早期预后的关系  

Correlation between serum suPAR and syndecan-4 levels and severity of disease and early prognosis in CAP patients

作　　者：邓星明 李杰敏 DENG Xingming;LI Jiemin(Intensive Care UnitⅡ,Qingyuan People’s Hospital,Guangdong,Qingyuan 511500,China)

机构地区：[1]广东省清远市人民医院ICU二区,广东清远511500

出　　处：《中国医药科学》2022年第5期182-185,共4页China Medicine And Pharmacy

基　　金：广东省清远市科技计划项目(2018B026)。

摘　　要：目的探讨社区获得性肺炎(CAP)患者血清可溶性尿激酶型纤溶酶原激活物受体(suPAR)、多配体蛋白聚糖4(syndecan-4)水平与CAP的严重程度及早期预后的关系。方法选取2018年5月至2021年2月在清远市人民医院确诊的128例CAP患者,根据CAP患者的病情严重程度分为重症CAP组(n=44)和非重症CAP组(n=84),分析比较患者的年龄、是否患有糖尿病、双肺是否出现感染、胸膜处是否有渗出情况、白细胞数量、CURB-65评分、肺炎严重度评分(PSI)及急性生理及慢性健康评估(APACHE)Ⅱ评分等,检测两组患者的suPAR及syndecan-4水平,并对其与其他指标进行相关性分析。结果重症CAP组的血清suPAR水平明显高于非重症CAP组,血清syndecan-4水平明显低于非重症CAP组,其年龄、降钙素原、中性粒细胞/淋巴细胞比值、胸膜处渗出比例、双肺感染比例、白细胞计数、CURB-65评分、PSI评分、APACHEⅡ评分以及C-反应蛋白等方面均明显高于非重症CAP组,差异有统计学意义(P<0.05)。血清suPAR水平与CURB-65评分、PSI评分、APACHEⅡ评分、中性粒细胞/淋巴细胞比值、C-反应蛋白以及降钙素原呈正相关(P<0.05);血清syndecan-4水平与CURB-65评分、PSI评分、APACHEⅡ评分及降钙素原呈负相关(P<0.05)。结论CAP患者的suPAR和syndecan-4水平同CAP的严重程度和该病的早期预后有紧密联系,CAP患者血清suPAR水平越高、syndecan-4水平越低,其病情越严重、预后越差。Objective To investigate the correlation between the levels of serum soluble urokinase-type plasminogen activator receptor(suPAR)and syndecan-4 and the severity and early prognosis of patients with community-acquired pneumonia(CAP).Methods A total of 128 patients with CAP diagnosed in Qingyuan People’s Hospital from May 2018 to February 2021 were selected as study subjects.They were divided into the severe CAP group(n=44)and the non-severe CAP group(n=84)according to the severity of CAP.The age,the presence or absence of diabetes,infection in both lungs and exudation at the pleura,white blood cell count,CURB-65 score,Pneumonia Severity Index(PSI)and score of Acute Physiological,Chronic Health Evaluation(APACHE)Ⅱ,etc.of these patients were comparatively analyzed.In addition,the suPAR and syndecan-4 levels of patients in both groups were examined,and the correlation of them with other indexes was analyzed.Results The serum suPAR level in the severe CAP group was significantly higher than that in the non-severe CAP group,and the serum syndecan-4 level was significantly lower than that in the non-severe CAP group,the age,procalcitonin,neutrophil/lymphocyte ratio,pleural effusion ratio,ratio of bilateral lung infection,white blood cell count,CURB-65 score,PSI score,APACHEⅡ score and C-reactive protein were significantly higher than those in the non-severe CAP group,and the difference was statistically significant(P<0.05).Serum suPAR level was positively correlated with CURB-65 score,PSI score,APACHEⅡ score,neutrophil/lymphocyte ratio,C-reactive protein and procalcitonin(P<0.05);serum syndecan-4 level was negatively correlated with CURB-65 score,PSI score,APACHEⅡ score and procalcitonin(P<0.05).Conclusion The levels of serum suPAR and syndecan-4 are closely related to the severity and early prognosis of CAP.The higher the serum suPAR level and lower the syndecan-4 level in CAP patients,the more severe the disease and the worse the prognosis of the patients.

关 键 词：可溶性尿激酶型纤溶酶原激活物受体 多配体蛋白聚糖4 早期预后 社区获得性肺炎 病情严重程度 

分 类 号：R563.1[医药卫生—呼吸系统]