Cationic and Anionic Antimicrobial Agents Co‑Templated Mesostructured Silica Nanocomposites with a Spiky Nanotopology and Enhanced Biofilm Inhibition Performance  

作　　者：Yaping Song Qiang Sun Jiangqi Luo Yueqi Kong Bolin Pan Jing Zhao Yue Wang Chengzhong Yu 

机构地区：[1]Australian Institute for Bioengineering and Nanotechnology,The University of Queensland,Brisbane,QLD 4072,Australia [2]Centre for Microscopy and Microanalysis,University of Queensland,Brisbane,QLD 4072,Australia [3]Australia Centre for Water and Environmental Biotechnology,University of Queensland,Brisbane,QLD 4072,Australia [4]School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200241,People’s Republic of China

出　　处：《Nano-Micro Letters》2022年第5期181-191,共11页纳微快报（英文版）

基　　金：Open access funding provided by Shanghai Jiao Tong University

摘　　要：Silica-based materials are usually used as delivery systems for antibacterial applications.In rare cases,bactericidal cationic surfactant templated silica composites have been reported as antimicrobial agents.However,their antibacterial efficacy is limited due to limited control in content and structure.Herein,we report a“dual active templating”strategy in the design of nanostructured silica composites with intrinsic antibacterial performance.This strategy uses cationic and anionic structural directing agents as dual templates,both with active antibacterial property.The cationic-anionic dual active templating strategy further contributes to antibacterial nanocomposites with a spiky surface.With controllable release of dual active antibacterial agents,the spiky nanocomposite displays enhanced anti-microbial and anti-biofilm properties toward Staphylococcus epidermidis.These findings pave a new avenue toward the designed synthesis of novel antibacterial nanocomposites with improved performance for diverse antibacterial applications.

关 键 词：Antibacterial surfactants Spiky nanoparticles ANTIBACTERIAL Anti-biofilm Mesostructured nanocomposites 

分 类 号：TB332[一般工业技术—材料科学与工程]