我国反复妊娠丢失诊疗现状的知识图谱分析  

Knowledge mapping analysis of diagnosis and treatment of recurrent pregnancy loss in China

作　　者：邓楹君 秦文敏 王颖[3] DENG Ying-jun;QIN Wen-min;WANG Ying(Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091;XuZhou Hospital of Traditional Chinese Medicine,Xuzhou 221003;Peking University Third Hospital,Beijing 100191)

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]徐州市中医院,徐州221003 [3]北京大学第三医院,北京100191

出　　处：《生殖医学杂志》2022年第4期514-521,共8页Journal of Reproductive Medicine

基　　金：国家自然科学基金面上项目(82174392);中国中医科学院科技创新工程重大攻关项目重点项目(CI2021A00901)。

摘　　要：目的使用知识图谱软件对近30年“中国知网”范围内搜索的关于反复妊娠丢失诊疗情况的论文进行分析,研究存在的问题及未来的发展趋势。方法以反复妊娠丢失为研究主题,检索中国知网自1992年1月至2021年9月来源为EI、北大核心、CSSCI、CSCD的期刊文献,利用CiteSpace软件和VOSviewer软件,通过合作网络、关键词聚类、关键词共现等方法对文献的发表年份、作者、机构、关键词等进行可视化图谱分析。结果共纳入中文文献975篇,包含核心作者63位。主要研究机构有上海交通大学医学院附属仁济医院、中山大学孙逸仙纪念医院、广东省计划生育科学技术研究所、北京大学第三医院、华中科技大学同济医院等。出现频率较高的关键词有染色体、抗磷脂抗体、不明原因反复妊娠丢失、阿司匹林、低分子肝素、主动免疫、封闭抗体等。结论反复妊娠丢失病因和病理机制复杂,目前研究主要集中在遗传、血栓前状态、免疫和不明原因性复发性流产的诊疗;与反复妊娠丢失相关的免疫学方面需要更深入的研究。Objective:To analyze the development of diagnosis and treatment of recurrent pregnancy loss in recent 30 years based on knowledge mapping analysis software,and explore its problems and future development trend.Methods:With repeated pregnancy loss as the research theme,the literatures of the journals of EI,Peking University Core,CSSCI and CSCD were searched in CNKI from January 1992 to September 2021.The visualization mapping analysis of the published years,authors,institutions and keywords of the literatures was carried out by using CiteSpace software and VOSviewer software through cooperative network,keyword clustering and keyword co-occurrence.Results:A total of 975 Chinese literatures including 63 core authors were retrieved.The main institutions were Renji Hospital Affiliated to School of Medicine,Shanghai Jiao Tong University;Sun Yixian Memorial Hospital,Sun Yat-sen University;Guangdong Provincial Institute of Family Planning Science and Technology;Peking University Third Hospital;Tongji Hospital,Huazhong University of Science and Technology.Key words with high frequency of occurrence were chromosomes,antiphospholipid antibodies,unexplained recurrent pregnancy loss,aspirin,low molecular weight heparin,active immunity,and blocking antibody,etc.Conclusions:The etiology and pathological mechanism of recurrent pregnancy loss are complex.At present,the research mainly focuses on the diagnosis and treatment of heredity,prethrombotic state,immunity and unexplained recurrent spontaneous abortion.The immunological aspects associated with recurrent pregnancy loss need to be further studied.

关 键 词：反复妊娠丢失 知识图谱分析 诊疗现状 

分 类 号：R714.21[医药卫生—妇产科学]