微生物源抗菌肽抗肿瘤特性的研究进展  

Progress in research of antitumor properties of antimicrobial peptides derived from microbes

作　　者：王露露 陈洲 贾英民[1] WANG Lulu;CHEN Zhou;JIA Yingmin(School of Food and Health,Beijing Technology and Business University,Beijing 100048,China)

机构地区：[1]北京工商大学食品与健康学院,北京100048

出　　处：《生物学杂志》2022年第2期100-105,119,共7页Journal of Biology

基　　金：国家自然科学基金项目(31771951&31801510);北京市自然科学基金-市教委联合重点项目(KZ201810011016)。

摘　　要：重点介绍近年来有关微生物源抗菌肽(antimicrobial peptides,AMPs)在抗肿瘤细胞方面的最新研究进展。依次分析细菌源、真菌源和放线菌源AMPs能够抑制的肿瘤细胞种类,AMPs对不同类别肿瘤细胞的抗性作用特点,以及AMPs对肿瘤细胞的抗性效果和差异;简述微生物源AMPs抗肿瘤细胞机制的研究现状,分别阐明微生物源AMPs通过作用肿瘤细胞的线粒体、内质网和死亡受体等途径来诱导肿瘤细胞凋亡的机制。通过对微生物源AMPs抗肿瘤作用及其效果相关研究内容的整理和其对肿瘤细胞抗性机制的总结,将有助于其他学者更深入和全面地了解微生物源AMPs新的功能,指出进一步挖掘微生物源AMPs的重要性,为微生物源AMPs未来的抗肿瘤研究及其应用提供新的思路。This article mainly introduced the latest research progress of antimicrobial peptides(AMPs)from microorganisms in anti-tumor cells in recent years.Firstly,the types of tumor cells inhibited by AMPs from bacterial,fungal and actinomycetes sources,the characteristics of resistance of AMPs to different types of tumor cells,and the resistance effects and differences of AMPs to tumor cells were analyzed successively.Secondly,the research status of anti-tumor cell mechanism of microbial AMPs was briefly introduced,and the mechanism of inducing tumor cell apoptosis by acting on mitochondria,endoplasmic reticulum and death receptors of tumor cells was also clarified.According to this paper,the microbial source AMPs anti-tumor effect and its effect were related to the research content and the summary of the mechanism of resistance of tumor cells.It would help others more in-depth and comprehensive understanding of the microbial source AMPs new functions and point out the importance of further excavating microbial source AMPs for anti-tumor research and application of microbial source AMPs in the future to provide new ideas.

关 键 词：微生物源 抗菌肽 抗肿瘤细胞活性 抗肿瘤机制 侧孢短芽孢杆菌 

分 类 号：Q516[生物学—生物化学] Q939.9