超声引导下经皮双极射频消融术治疗慢性肾脏病继发性甲状旁腺功能亢进短期疗效分析  

Short-term Efficacy Analysis of Ultrasound-guided Percutaneous Bipolar Radiofrequency Ablation for Secondary Hyperparathyroidism in Chronic Kidney Disease

作　　者：李梦媛 王运昌[1] 姜宏卫[2] LI Mengyuan;WANG Yunchang;JIANG Hongwei(Department of Ultrasound,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan 471000,China;Department of Endocrinology,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan Province 471000,China)

机构地区：[1]河南科技大学第一附属医院超声科,河南洛阳471000 [2]河南科技大学第一附属医院内分泌科,河南洛阳471000

出　　处：《临床研究》2022年第2期35-39,共5页Clinical Research

摘　　要：目的分析超声引导下经皮双极射频消融术(bRFA)治疗慢性肾脏病(CKD)继发性甲状旁腺功能亢进症(SHPT)患者的近期临床效果。方法回顾性分析2019年9月至2021年2月间在本院收治的60例SHPT患者的临床资料,根据治疗方式的不同将其中30例行超声引导下经皮bRFA治疗患者纳入观察组;另外30例行甲状旁腺切除术(PTX)治疗的患者纳入对照组;收集两组治疗前、治疗1 d后、1周后、1个月后、3个月和6个月后相关实验室指标水平,观察两种不同治疗方式短期疗效差异和并发症发生情况。结果观察组和对照组治疗1 d后、1周后、1个月后、3个月后和6个月后甲状旁腺激素(PTH)、血钙、血磷和血清碱性磷酸酶(ALP)水平较本组治疗前相比均有明显下降,差异有统计学意义(P<0.05);但两组治疗前和治疗后不同阶段的PTH、血钙、血磷和ALP水平组间对比差异无统计学意义(P>0.05)。观察组并发症发生率16.67%低于对照组46.67%,差异有统计学意义(P<0.05)。结论与PTX相比,超声引导下经皮bRFA治疗SHPT患者可以在取得相近临床效果的同时减少并发症的发生,治疗的安全性更高,值得临床应用。Objective To analyze the short-term clinical effects of ultrasound-guided percutaneous bipolar radiofrequency ablation(bRFA)in patients with chronic kidney disease(CKD)secondary hyperparathyroidism(SHPT).Methods Retrospectively analyzing the clinical data of 60 SHPT patients admitted to our hospital from September 2019 to February 2021.According different treatment,30 patients treated with ultrasound-guided percutaneous bRFA were included in the observation group,another 30 patients treated with parathyroidectomy(PTX)were included in the control group.The levels of relevant laboratory indicators before treatment and 1 day,1 week,1 month,3 months and 6 months after treatment were collected from two groups to observe the short-term efficacy differences and the occurrence of complications of the two different treatment modalities.Results The observation group and the control group showed a significant decrease in parathyroid hormone(PTH),blood calcium,blood phosphorus and serum alkaline phosphatase(ALP)levels after 1 day,1 week,1 month,3 months and 6 months than before,with significant differences(P<0.05).However,there was no significant difference in PTH,blood calcium,blood phosphorus and ALP levels before and after treatment between two groups(P>0.05).The total incidence of complications in the observation group was 16.67%lower than 46.67%in the control group,with significant difference(P<0.05).Conclusion Compared with PTX,ultrasound-guided percutaneous bRFA treatment in patients with SHPT can reduce the occurrence of complications and have higher safety,which is worthy of clinical application.

关 键 词：慢性肾脏病 继发性甲状旁腺功能亢进症 超声引导下经皮双极射频消融术 甲状旁腺切除术 短期疗效 并发症 

分 类 号：R582[医药卫生—内分泌]