舒芬太尼联合咪达唑仑用于重症颅脑损伤患者中的镇痛镇静效果及对应激反应的影响  

Sufentanil Combined With Midazolam for Analgesia and Sedation in Patients With Severe Head injury and Its Influence on Stress Response

作　　者：黄滔 谷岩[1] 吴海宾[1] 曾汇霞 廖梅嫣 卢伟坤 Huang Tao;Gu Yan;Wu Haibin;Zeng Huixia;Liao Meiyan;Lu Weikun(The Second People's Hospital of Zhaoqing City,Zhaoqing 526000,China)

机构地区：[1]肇庆市第二人民医院,广东肇庆526000

出　　处：《哈尔滨医药》2022年第1期14-15,共2页Harbin Medical Journal

摘　　要：目的探讨舒芬太尼联合咪达唑仑用于重症颅脑损伤患者中的效果及对应激反应的影响。方法选择我院ICU收治的重症颅脑损伤患者85例,入院后均进行综合治疗,并采用1~3μg/(kg·h)舒芬太尼联合50mg咪达唑仑镇静镇痛。观察给药前后不同时点应激反应、镇静镇痛效果、颅内压水平以及药物不良反应发生情况。结果给药前后不同时点应激反应指标相比,差异无统计学意义(P>0.05);给药后不同时点镇静、镇痛评分均低于给药前,差异有统计学意义(P<0.05);给药后,患者颅内压水平呈连续下降趋势,差异有统计学意义(P<0.05);85例患者总不良反应发生率为5.88%,调整药量后不良反应均消失,未造成严重不良事件。结论重症颅脑损伤使用舒芬太尼联合咪达唑仑能够获得理想效果,利于降低颅内压,且不会引起严重应激反应,维持良好的镇静状态,减轻患者疼痛程度,且不良反应发生率较低,值得广泛应用。Objective To investigate the effect of sufentanil combined with midazolam in patients with severe head injury and its influence on stress response.Methods A total of 85 patients with severe craniocerebral injury admitted to the ICU of our hospital were selected.After admission,they were treated with comprehensive treatment,and 1-3μg/(kg·h)sufentanil combined with50 mg mida were used.Zolam is sedative and analgesic.Observe the stress response,sedative and analgesic effects,intracranial pressure levels and adverse drug reactions at different time points before and after administration.Results There was no significant difference in stress response indexes at different time points before and after administration(P>0.05);the scores of sedation and analgesia at different time points after administration were lower than those before administration,and the difference was statistically significant(P<0.05);After the administration,the intracranial pressure level of the patients showed a continuous downward trend,and the difference was statistically significant(P<0.05);the total adverse reaction rate of 85 patients was 5.88%,after adjusting the dose The adverse reactions disappeared and no serious adverse events were caused.Conclusion Sufentanil combined with midazolam for severe craniocerebral injury can achieve the desired effect,which is beneficial to reduce intracranial pressure without causing severe stress response,maintaining good sedation,reducing the pain of the patient,and adverse reactions.The rate is low and it is worthy of wide application.

关 键 词：重症颅脑损伤 舒芬太尼 咪达唑仑 镇痛镇静 应激反应 不良反应 

分 类 号：R651.75[医药卫生—外科学]