雷尼替丁对老年复发性口腔溃疡患者血清IFN-γ、TNF-α、IL-2水平的影响  

Influence of Ranitidine on Expression of Serum IFN-γ,TNF-α and IL-2 in Elderly Patients with Recurrent Oral Ulcer

作　　者：李明奚 秦勤召 LI Mingxi;QIN Qinzhao(Pharmacy Department Clinical Pharmaceutics Room,Dandong People’s Hospital,Dandong,Liaoning 118000,China)

机构地区：[1]丹东市人民医院药剂科临床药学室,辽宁丹东118000

出　　处：《中国烧伤创疡杂志》2022年第2期89-92,共4页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的 探讨雷尼替丁治疗老年复发性口腔溃疡的临床疗效及其对患者血清γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素-2 (IL-2)水平的影响方法 选取2019年7月至2020年11月丹东市人民医院收治的70例老年复发性口腔溃疡患者作为研究对象,按照随机数表法将其随机分为观察组(35例)和对照组(35例),观察组患者在冰硼散联合维生素C治疗的基础加用雷尼替丁治疗,对照组患者采用冰硼散联合维生索C治疗,对比两组患者IFN-γ、TN F-α、IL-2水平变化情况以及临床疗效与不良反应发生情况结果 治疗7d后,观察组患者IFN-γ水平为(77.18±11.39)mmol/L,明显高于对照组患者的IFN-γ水平(63.18±12.39) mmoI/L (t=4.921,P<0.001);TNF-α水平为(2.78±0.42) mg/ml、IL-2水平为(0.25±0.06) mg/ml,明显低于对照组患者的TNF-α水平(5.97±1.46) mg/ml、IL-2水平(0.73±0.10) mg/ml(t=12.420、24.350,P均<0.001)。治疗7d后,观察组患者总有效率为97.14%.明显高于对照组患者的总有效率82.86%(χ^(2)=3.968,P=0.046)治疗过程中,观察组患者不良反应发生率为11.43%,与对照组患者的不良反应发生率11.43%无明显差异(χ^(2)=0.000,P=1.000)。结论 雷尼替丁治疗老年复发性口腔溃疡,可明显改善机体lFN-γ、TNF-α、IL-2等因子的表达水平,提高临床疗效,且安全性较高,值得临床推广应用。Objective To investigate the clinical efficacy of Ranitidine in treating recurrent oral ulcer in elderly patients,and its influence on expression of serum interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α) and interleukin-2(IL-2) of such patients.Methods 70 elderly patients with recurrent oral ulcer,admitted to Dandong People’ s Hospital between July 2019 and November 2020,were enrolled and divided,using the random number table,into study group(n=35) and control group(n=35).Patients in study group were treated with Bingpeng San and Vitamin C plus Ranitidine,whereas patients in c-ontrol group were treated with Bingpeng San and Vitamin C.The changes of IFN-γ,TNF-α and IL-2,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results After 7 days of treatment,the level of IFN-γ was(77.18±11.39) mmol/L in study group,obviously higher than(63.18±12.39) mmol/L in control group(t=4.921,P <0.001),and the levels of TNF-αand IL-2 were respectively(2.78±0.42) mg/ml and(0.25±0.06) mg/ml,significantly lower than the corresponding(5.97±1.46) mg/ml and(0.73±0.10) mg/ml in control group(t=12.420 and 24.350,both P <0.001).After 7 days of treatment,the total effective rate in study group was 97.14%,remarkably higher than 82.86% in control group(χ^(2)=3.968,P=0.046).During the course of treatment,the incidence of adverse reactions in study group was 11.43%,which showed no statistically significant difference as compared with 11.43% in control group(χ^(2)=0.000 P=1.000).Conclusion In the treatment of recurrent oral ulcer in elderly patients,Ranitidine can significantly ameliorate the expression of serum IFN-γ,TNF-α and IL-2,and improve clinical efficacy.Besides,it is very safe,deserving to be promoted in clinical practice.

关 键 词：雷尼替丁 复发性口腔溃疡 Γ-干扰素 肿瘤坏死因子-α 白细胞介素-2 

分 类 号：R969[医药卫生—药理学]