急性胃十二指肠溃疡穿孔术后感染危险因素分析  

Analysis of Risk Factors for Infection Following Surgery for Acute Perforation of Gastroduodenal Ulcer

作　　者：王佳佳 WANG Jiajia(Digestive System Department,The 7th People’s Hospital of Zhengzhou,Zhengzhou,Henan 450016,China)

机构地区：[1]郑州市第七人民医院消化内科,河南郑州450016

出　　处：《中国烧伤创疡杂志》2022年第2期116-119,共4页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的 回顾性分析急性胃十二指肠溃疡穿孔患者术后感染的相关危险因素方法 选取2019年7月至2021年3月郑州市第七人民医院收治的40例急性胃十二指肠溃疡穿孔术后感染患者以及156例术后非感染患者作为研究对象,分别设为感染组与非感染组,收集患者性别、年龄、溃疡病程、抗菌药物使用情况、有无输血及肥胖、手术操作医师职称等相关资料,多因素Logistic回归分析急性胃十二指肠溃疡穿孔患者术后感染的相关危险因素结果 多因素Logistic回归分析结果显示,年龄>55岁、溃疡病程>2年、术后抗菌药物使用时间>2d、肥胖、非Ⅰ级层流手术室和术前存在感染是急性胃十二指肠溃疡穿孔患者术后感染的独立危险因素(95%CI:3.127~6.058、3.949~8.117、1.561~3.998、2.994~15.764、1.603~4.575、1.575~4.086,P=0.003、0.001、0.029、0.006、0.036、0.043)。结论 高龄、溃疡病程长、术后抗菌药物使用时间长、肥胖、非Ⅰ级层流手术室以及术前存在感染是急性胃十二指肠溃疡穿孔术后感染的独立危险因素,术前应及时对危险因素进行干预,以预防术后感染的发生。Objective To retrospectively analyze the relevant risk factors for infection following surgery for acute perforation of gastroduodenal ulcer.Methods 40 patients with infection after surgery for acute perforation of gastroduodenal ulcer and 156 patients without infection after such surgery,admitted into The 7 th People’s Hospital of Zhengzhou between July 2019 and March 2021 were selected as research subjects,and respectively set as infection group and non-infection group.Data such as sex,age,duration of ulcer,administration of antibacterial agents,with blood transfusion and obesity or not,professional title of surgeon were collected.The relevant risk factors for infection following surgery for acute perforation of gastroduodenal ulcer were analyzed using multivariate Logistic regression.Results Multivariate Logistic regression analysis found that age>55 years old,duration of ulcer>2 years,administration time of antibacterial agents after surgery>2 d,obesity,without grade I laminar flow environment of operating room,and preexisting infection before surgery were independent risk factors of infection following surgery for acute perforation of gastroduodenal ulcer(95% CI:3.127-6.058,3.949-8.117,1.561-3.998,2.994-15.764,1.603-4.575.1.575-4.086,P=0.003,0.001,0.029,0.006,0.036 and 0.043).Conclusion Advanced age,long duration of ulcer,long administration of antibacterial agents after surgery,obesity,without grade Ⅰ laminar flow environment of operating room and preexisting infection before surgery are the independent risk factors of infection following surgery for acute perforation of gastroduodenal ulcer,and thus it is advisable to properly manage these factors before surgery to avoid the occurrence of postoperative infection.

关 键 词：急性胃十二指肠溃疡穿孔 手术 切口感染 腹腔感染 危险因素 

分 类 号：R656.6[医药卫生—外科学]