白三烯受体拮抗剂和抗组胺药联合微波热凝治疗变应性咽炎的临床效果  

Clinical Effect of Leukotriene Receptor Antagonist and Antihistamine Combined with Microwave Heat Coagulationin the Treatment of Allergic Pharyngitis

作　　者：杨好喜 YANG Hao-xi(Otolaryngology Department,Affiliated Hospital of Nankai University,Tianjin Fourth Hospital,Tianjin,300222,China)

机构地区：[1]南开大学附属医院·天津市第四医院耳鼻咽喉科,天津300222

出　　处：《黑龙江医学》2022年第6期689-692,共4页Heilongjiang Medical Journal

摘　　要：目的:观察白三烯受体拮抗剂和抗组胺药联合微波热凝治疗变应性咽炎(allergic pharyngitis,AP)的临床效果。方法:选取2015年10月—2017年4月南开大学附属医院(天津市第四医院)耳鼻喉科门诊收治的100例AP患者作为研究对象,随机分为治疗组和对照组,每组各50例,治疗组采用白三烯受体拮抗剂和抗组胺药联合微波热凝治疗,对照组患者采用白三烯受体拮抗剂和抗组胺药治疗。在治疗1d、3d、1周、2周时对患者咽痒、咳嗽症状进行视觉模拟量表(visual analoguescale,VAS)评分,观察比较两组患者治疗前后咽痒、咳嗽症状改善程度及体征变化区别。结果:治疗组在治疗3d时咽痒症状VAS评分与对照组在治疗2周时咽痒症状VAS评分比较,差异无统计学意义(t=-34.452、-0.988,P>0.05)。治疗组在治疗1周时咳嗽症状VAS评分与对照组在治疗2周时咳嗽症状VAS评分比较,差异有统计学意义(t=-9.868、-3.128,P<0.05)。结论:在应用抗组胺药和白三烯受体拮杭剂治疗AP后,患者的临床症状得到了明显改善,AP的症状有效减轻,同时联合微波热凝治疗,不但可以缩短AP治疗疗程,还有显著的治疗效果,期望为AP临床治疗应用提供参考依据。Objective:To observe the clinical effect of leukotriene receptor antagonist and antihistamine combined with microwave heat coagulation in the treatment of allergic pharyngitis.Methods:100 patients with allergic pharyngitis in the hospital from October 2015 to April 2017 were selected as the research objects. They were randomly divided into treatment group and control group, with 50 cases in each group. The treatment group was treated with leukotriene receptor antagonists and antihistamines combined with microwave thermocoagulation, and the control group was treated with leukotriene receptor antagonists and antihistamines. The visual analogue scale(VAS) scores were performed on the patients’ pharyngeal itch and cough symptoms at 1 d, 3 d,1 week, and 2 weeks of treatment. The differences in the improvement of pharyngeal itch and cough symptoms and changes in signs between the two groups before and after treatment were observed and compared.Results:There was no statistically significant difference in the VAS score of pharyngeal itching symptoms in the treatment group for 3 and the control group on the VAS score of pharyngeal itch symptoms in the 2 weeks of treatment(t=-34.452,-0.988, P>0.05). There was statistically significant difference in the VAS score of cough symptoms in the treatment group at 1 week of treatment and the control group at 2 weeks of treatment(t=-9.868,-3.128, P<0.05).Conclusion:After the application of antihistamines and leukotriene receptor antagonists to treat AP, the patients’ clinical symptoms have been significantly improved, which can effectively alleviate the symptoms of AP. At the same time, the combination of microwave thermocoagulation therapy can not only shorten the course of AP treatment, but also achieve better therapeutic effects. It is hoped that it will provide a reference for the clinical application of AP.

关 键 词：微波 变应性咽炎 白三烯受体拮抗剂 抗组胺 咳嗽 

分 类 号：R762[医药卫生—耳鼻咽喉科]