羟苯磺酸钙联合骨化三醇治疗糖尿病非增殖期视网膜病变的临床研究  

Clinical Study of Calcium Dobesilate Combined With Calcitriol in the Treatment of Diabetic Non-proliferative Retinopathy

作　　者：关红[1] 白爱琳 孙亚东[1] GUAN Hong;BAI Ailin;SUN Yadong(The First Department,Endocrine and Metabolic Diseases,Jilin Province People's Hospital,Changchun Jilin 130000,China;Clinical College,Changchun University of Chinese Medicine,Changchun Jilin 130000,China)

机构地区：[1]吉林省人民医院内分泌代谢病一科,吉林长春130021 [2]长春中医药大学临床医学院,吉林长春130117

出　　处：《中国继续医学教育》2022年第5期194-198,共5页China Continuing Medical Education

基　　金：吉林省卫生健康技术创新科研课题(2019J070)。

摘　　要：目的探讨羟苯磺酸钙联合骨化三醇治疗非增殖期糖尿病视网膜病变的临床疗效。方法选取2019年6月—2020年12月在我院收治已确诊为糖尿病非增殖期视网膜病变的180例患者为研究对象,按随机数字表法将患者随机分为3组,每组60例。A组患者接受羟苯磺酸钙片治疗,剂量为0.5 g,口服,3次/天;B组患者接受骨化三醇治疗,剂量为0.25μg,口服,1次/天;C组接受羟苯磺酸钙片联合骨化三醇治疗,剂量与A、B两组相同。12周为1个疗程,共2个疗程。观察三组患者治疗的总有效率,比较治疗前后的视力、眼压检查和眼底检查相关指标、视网膜出血情况及渗出情况。结果治疗后,C组总有效率为96.7%,优于A组的86.7%,B组的81.6%(P<0.05)。治疗C组视力提升优于A组和B组(P<0.05),且C组眼底渗出物面积、出血斑面积、微血管瘤个数均明显低于A组和B组(P<0.05)。结论联合使用羟苯磺酸钙和骨化三醇治疗糖尿病非增殖期视网膜病变的患者可取得显著疗效,明显改善视力,减少眼底病变、眼底渗出物、出血量、微血管瘤,值得临床推广。Objective To investigate the clinical effect of calcium dobesilate combined with calcitriol in the treatment of non-proliferative diabetic retinopathy.Methods A total of 180 patients with confirmed non-proliferative diabetic retinopathy admitted to our hospital from June 2019 to December 2020 were selected,and randomly divided into 3 groups(n=60).Patients in group A were treated with calcium dobesilate tablets at a dose of 0.5 g,orally,3 times daily.Patients in group B were treated with calcitriol at a dose of 0.25μg,orally,once per day.Group C were treated with calcium dobesilate tablets combined with calcitriol at the same dose as groups A and B.The treatment course of 3 groups was 24 weeks.After treatment,the clinical effects in three groups were observed,and visual acuity,intraocular pressure and fundus examination related indicators,retinal hemorrhage and exudation before and after treatment were compared.Results After treatment,the total effective rate in group C was 96.7%,better than 86.7%in group A,and 81.6%in group B(P<0.05).After treatment,vision improvement in group C was better than that in group A and group B(P<0.05).The area of fundus exudate,the area of bleeding plaques and the number of microhemangiomas in group C were significantly lower than those in group A and group B(P<0.05).Conclusion The combined use of calcium dobesilate and calcitriol in the treatment of patients with diabetic non-proliferative retinopathy can achieve curative effect significantly,improve vision,reduce fundus lesions,fundus exudates,bleeding volume,and microhemangioma,which is worthy of clinical promotion and should be popularized in clinical practice.

关 键 词：羟苯磺酸钙 骨化三醇 糖尿病 非增殖期 视网膜病变 疗效 

分 类 号：R587[医药卫生—内分泌]