DNA损伤修复研究进展及其对围术期认知功能障碍的影响  

Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction

作　　者：戎玉兰[1] 史成梅[1] 郭向阳[1] RONG Yu-lan;SHI Cheng-mei;GUO Xiang-yang(Department of Anesthesiology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院麻醉科,北京100191

出　　处：《基础医学与临床》2022年第4期675-678,共4页Basic and Clinical Medicine

摘　　要：DNA损伤与修复的动态平衡是保持基因组稳定性的重要因素之一。针对DNA双链断裂损伤(DSB),主要存在同源重组(HR)和非同源末端连接(NHEJ)两种修复方式。NHEJ是中枢神经系统成熟神经元DSB的主要修复途径。通过研究NHEJ分子机制和围术期认知功能障碍(POCD),发现围术期因素会影响NHEJ修复通路。NHEJ有可能成为干预和改善POCD的新靶点。The dynamic balance between DNA double-strand break(DSB)accumulation and repair is one of the important factors to maintain genomic stability.The homologous recombination(HR)and the non-homologous ending joining(NHEJ)are the two major pathways to repair DSB.In mature neurons of the central nervous system,the NHEJ is the main repair pathway of DSB.Recent studies in the molecular mechanism of NHEJ and peri-operative cognitive dysfunction(POCD)revealed several molecular mechanisms underlying the DNA damage repair and its links to POCD,which may provide a new therapeutic target.

关 键 词：DNA损伤修复 非同源末端连接 围术期认知功能障碍 

分 类 号：R614[医药卫生—麻醉学]