他克莫司软膏联合短程地塞米松软膏治疗面部脂溢性皮炎的临床效果与安全性分析  

Clinical Effect and Safety Analysis of Tacrolimus Ointment Combined with Shortterm Dexamethasone Ointment in the Treatment of Facial Seborrheic Dermatitis

作　　者：张美琼 ZHANG Meiqiong(Department of Dermatology,Daqing Longnan Hospital(Fifth Affiliated Hospital of Qiqihar University),Daqing,Heilongjiang Province,163002 China)

机构地区：[1]大庆龙南医院(齐齐哈尔大学第五附属医院)皮肤科,黑龙江大庆163002

出　　处：《世界复合医学》2022年第1期177-181,共5页World Journal of Complex Medicine

摘　　要：目的分析在面部脂溢性皮炎治疗中,予以他克莫司软膏联合短程地塞米松软膏治疗的临床效果及价值。方法选取该院2020年1—12月收治的72例面部脂溢性皮炎患者为研究对象,采取随机数表法均分为两组,对照组(36例)实施单一他克莫司软膏治疗,观察组(36例)基于此联合短程地塞米松软膏治疗;对比观察在不同治疗方案下,两组患者治疗效果、皮肤状态、皮肤症状评分、不良反应发生率以及生活质量改善效果。结果两组治疗效果对比,观察组高于对照组(94.44%>75.00%),差异有统计学意义(χ^(2)=5.258,P<0.05)。对比皮肤状态,治疗前,两组表皮水分丢失值以及角质层含水量,差异无统计学意义(P>0.05);治疗后,观察组表皮水分丢失值显著低于对照组,角质层含水量显著高于对照组,差异有统计学意义(t=12.304、8.358,P<0.001)。对比皮肤症状评分,治疗前,两组皮肤斑点、瘙痒、刺痛、糠样脱屑、红肿等症状评分对比,差异无统计学意义(P>0.05);治疗后,观察组皮肤斑点、瘙痒、刺痛、糠样脱屑、红肿等症状评分均显著低于对照组,差异有统计学意义(t=10.046、11.595、15.181、9.393、12.189,P<0.001)。对比两组患者不良反应发生率(8.33%vs 11.11%),差异无统计学意义(χ^(2)=0.158,P>0.05)。对比两组患者生活质量评分,治疗前,两组生理健康、心理健康、躯体情况、社会参与及一般健康等维度的SF-36评分对比,差异无统计学意义(P>0.05);治疗后,观察组生理健康、心理健康、躯体情况、社会参与及一般健康评分均显著高于对照组,差异有统计学意义(t=4.726、4.345、4.244、4.922、4.434,P<0.001)。结论在面部脂溢性皮炎治疗中,予以他克莫司软膏联合短程地塞米松软膏治疗效果显著,可有助于促进患者病症的改善,且用药安全性高,不良反应少。Objective To analyze the clinical effect and value of tacrolimus ointment combined with short-term dexamethasone ointment in the treatment of facial seborrheic dermatitis.Methods 72 patients with facial seborrheic dermatitis admitted and treated in the hospital from January to December 2020 were selected and randomly divided into two groups.The control group(36 cases)was treated with tacrolimus ointment,and the observation group(36 cases)was treated with short-term dexamethasone ointment based on this.The therapeutic effect,skin condition,skin symptom score,incidence of adverse reactions and improvement of quality of life of the two groups were compared under different treatment regimens.Results The treatment effect of the two groups was compared.The observation group was higher than that of the control group(94.44%>75.00%),and the difference was statistically significant(χ^(2)=5.258,P<0.05).After treatment,the epidermal water loss value of the observation group was significantly lower than that of the control group,and the water content of the stratum corneum was significantly higher than that of the control group,and the difference was statistically significant(t=12.304,8.358,P<0.05).After treatment,the scores of skin spots,itching,stabbing pain,bran-like chipping,swelling and other symptoms of the observation group were significantly lower than those of the control group,the difference was statistically significant(t=10.046,11.595,15.181,9.393,12.189,P<0.001).There was no significant difference in the incidence of adverse reactions between the two groups(8.33%vs 11.11%)(χ^(2)=0.158,P>0.05).The SF-36 scores of physical health,mental health,physical condition,social participation and general health in the two groups before treatment were compared,and the difference was not statistically significant(P>0.05).After treatment,the scores of physical health,mental health,physical condition,social participation and general health in the observation group were significantly higher than those in the control group,and t

关 键 词：他克莫司 地塞米松 面部脂溢性皮炎 临床效果 安全性 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]