儿童功能性消化不良与血清脑-肠肽水平的关系  

Association between functional dyspepsia and serum levels of brain-gut peptides in children

作　　者：王东伟 叶晓琳 吴捷[1,2] WANG Dong-Wei;YE Xiao-Lin;WU Jie(Department of Pediatric Gastroenterology,Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院小儿消化内科,辽宁沈阳110004 [2]首都医科大学附属北京儿童医院消化科,北京100045

出　　处：《中国当代儿科杂志》2022年第4期387-391,共5页Chinese Journal of Contemporary Pediatrics

摘　　要：目的 基于脑-肠轴水平探究儿童功能性消化不良(functional dyspepsia,FD)与降钙素基因相关肽(calcitonin gene-related peptide,CGRP)、摄食抑制因子(nesfatin-1)及生长激素释放肽(ghrelin)等脑-肠肽水平的关系。方法 回顾性选取2019年11月至2020年12月就诊于中国医科大学附属盛京医院FD患儿38例纳入FD组,另选取健康儿童34例纳入健康对照组。采集两组患儿的血清标本,应用酶联免疫吸附测定法分别测定两组儿童CGRP、ghrelin及nesfatin-1的血清水平并进行比较。同时对FD患儿FD症状进行评分,采用Spearman秩相关分析症状评分与脑-肠肽血清水平的相关性。结果 FD组患儿血清nesfatin-1和CGRP水平均高于健康对照组(P<0.05);两组血清ghrelin水平差异无统计学意义(P>0.05)。nesfatin-1血清水平与早饱症状评分呈正相关(rs=0.553,P<0.001),与FD总评分未见明显相关性(rs=0.191,P=0.250);CGRP血清水平与腹痛症状评分呈正相关(rs=0.479,P=0.002),与嗳气症状评分呈正相关(rs=0.619,P<0.001),与FD总评分呈正相关(rs=0.541,P<0.001)。结论 CGRP及nesfatin-1在FD的病理生理过程中可能发挥重要作用。Objective To study the association between functional dyspepsia(FD) and serum levels of brain-gut peptides including calcitonin gene-related peptide(CGRP),nesfatin-1,and ghrelin in children.Method A total of 38children with FD who attended Shengjing Hospital of China Medical University from November 2019 to December 2020were enrolled as the FD group.Thirty-four healthy children were enrolled as the control group.Serum samples were collected from all of the children.Enzyme-linked immunosorbent assay was used to measure serum levels of CGRP,ghrelin,and nesfatin-1 for comparison between the two groups.The scores of clinical symptoms were determined for the children with FD.Spearman rank correlation analysis was used to investigate the correlation of symptom scores with the serum levels of brain-gut peptides.Results The FD group had significantly higher serum levels of nesfatin-1 and CGRP than the control group(P<0.05),while there was no significant difference in the serum level of ghrelin between the two groups(P>0.05).The serum level of nesfatin-1 was positively correlated with the symptom score of early satiety(rs=0.553,P<0.001),but was not significantly correlated with the total score of FD(rs=0.191,P=0.250).The serum level of CGRP was positively correlated with the scores of abdominal pain(rs=0.479,P=0.002) and belching(rs=0.619,P<0.001) and the total score of FD(rs=0.541,P<0.001).Conclusions CGRP and nesfatin-1 may play an important role in the pathophysiological process of FD.

关 键 词：功能性消化不良 降钙素基因相关肽 摄食抑制因子 生长激素释放肽 儿童 

分 类 号：R725.7[医药卫生—儿科]