扩散相关光谱组织血流检测及其临床应用  

Diffusion Correlation Spectroscopy for Tissue Blood Flow Monitoring and Its Clinical Applications

作　　者：李哲 冯金超[1,2,3] 贾克斌 Li Zhe;Feng Jinchao;Jia Kebin(Faculty of Information Technology,Beijing University of Technology,Beijing 100124,China;Beijing Laboratory of Advanced Information Networks,Beijing 100124,China;Beijing Key Laboratory of Computational Intelligence and Intelligent System,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学信息学部,北京100124 [2]先进信息网络北京实验室,北京100124 [3]北京工业大学计算智能与智能系统北京市重点实验室,北京100124

出　　处：《激光与光电子学进展》2022年第6期101-114,共14页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(62105010,81871394)。

摘　　要：扩散相关光谱(DCS)技术是一种新兴的组织血流无创检测技术。该技术将近红外光照射到组织表面,通过计算组织表面散射光斑的光强自相关函数推算组织中红细胞的运动状态,以实现组织血流变化的定量检测。相比于其他血流检测技术,如激光多普勒(LDF)、核磁共振成像(MRI)、正电子发射断层成像技术(PET)等,该技术具有无创、无辐射、可长时间连续实时检测、适用范围广、检测要求低等优势,适宜床边监测。分别从DCS技术的基本原理、系统与方法、临床应用等方面对其进行简要综述,并对DCS技术的未来发展趋势进行展望。Diffusion correlation spectroscopy(DCS)is a relatively new methodology that has been extensively used for the noninvasive monitoring of tissue blood flow.This technology irradiates the tissue surface with near-infrared light,calculates the light intensity autocorrelation function of the scattered spot on the tissue surface,and computes the movement of red blood cells to realize the quantitative detection of blood flow changes in tissues.DCS measurements show more promise for the noninvasive,radiation-free,continuous and real-time monitoring,wide application range,and low detection requirements of tissue blood flow than the other blood flow monitoring methods such as laser Doppler flowmetry(LDF),magnetic resonance imaging(MRI),and positron emission tomography(PET).Moreover,DCS technology can be utilized for the bedside monitoring of tissue blood flow.The DCS technique is mainly introduced in which its theoretical background,instrumentation,progress,and clinical applications are included,as well as its future development prospects are discussed.

关 键 词：生物技术 扩散相关光谱技术 近红外光谱技术 组织血流 心脑血管类疾病 癌症 

分 类 号：R318[医药卫生—生物医学工程]