Nd∶YAG激光在离体血液中传播的修正朗伯比尔定律研究  

Modified Beer-Lambert Law for Nd∶YAG Laser Transmission in Blood

作　　者：董晓曦[1] 孔亚群 阴慧娟[1] 董伟楠 赵继志[3] 杨基春[1] Dong Xiaoxi;Kong Yaqun;Yin Huijuan;Dong Weinan;Zhao Jizhi;Yang Jichun(Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192,China;Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院生物医学工程研究所,天津300192 [2]首都医科大学附属北京友谊医院,北京100050 [3]中国医学科学院,北京协和医学院北京协和医院,北京100730

出　　处：《激光与光电子学进展》2022年第6期304-310,共7页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(81801038)。

摘　　要：本研究的目的在于获得Nd∶YAG激光在血液中传播的几何尺寸损耗与血液厚度的关系,从而获得适用于Nd∶YAG激光在血液中传播的修正朗伯比尔定律的准确表达式。通过所建立的Nd∶YAG激光在离体血液中透过的光检测实验系统,检测得到激光在穿透目标厚度为1.0~2.5 mm(临床脉管性病变的常见血层厚度)的圆柱形血层后的光衰减情况,并基于R语言和统计学方法,建立了几何尺寸损耗与血液厚度之间的线性、对数、指数和乘幂回归模型。其中,线性回归模型的拟合效果最好,R^(2)值可达0.9219,由此获得适用于Nd∶YAG激光在血液中传播的修正朗伯比尔定律表达式。To acquire the exact expression of the modified Beer-Lambert law for the transmission of Nd∶YAG laser in blood,the relationship between a geometry-dependent factor and blood depth must be clarified.In this study,we built a laser energy detecting system that can measure the transmitted Nd∶YAG laser energy using in vitro blood samples.Laser decay was measured in cylinder-shaped blood layer with a thickness of 1.0-2.5 mm,which is the typical blood layer thickness in clinical vascular diseases.Statistical methods and the R language were used to build linear,log,index,and power regression models of the geometry-dependent factor with blood thickness as an independent variable.The highest R^(2) value among these four models is 0.9219,corresponding to the linear regression model.Based on the abovementioned results,the exact expression of the specially modified BeerLambert law has been built for Nd∶YAG laser transmission in blood.

关 键 词：Nd∶YAG激光 修正朗伯比尔定律 混沌介质 几何尺寸因子 静脉血 R语言 

分 类 号：R318.51[医药卫生—生物医学工程]