基于低相干干涉测量的眼轴长度测量系统研究  

Axial Eye Length Measurement System Based on Low Coherence Interferometry

作　　者：王成[1] 周岐 陈奕君 陈明惠[1] 项华中[1] 郑刚[1] 赵婕[2] 张大伟[3] Wang Cheng;Zhou Qi;Chen Yijun;Chen Minghui;Xiang Huazhong;Zheng Gang;Zhao Jie;Zhang Dawei(Institute of Biomedical Optics and Optometry,Key Lab of Medical Optical Technology and Instruments,Ministry of Education,University of Shanghai for Science and Technology,Shanghai 200093,China;Ophthalmology,Shayighai Yangpu District Shidong Hospital,Shanghai 200438,China;Key Laboratory of Modern Optical Systems,Engineering Research Center of Optical Instrument and System,Ministry of Education,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学生物医学光学与视光学研究所,教育部医用光学技术与仪器重点实验室,上海200093 [2]上海市杨浦区市东医院眼科,上海200438 [3]上海理工大学,教育部光学仪器与系统工程研究中心,上海市现代光学系统重点实验室,上海200093

出　　处：《中国激光》2022年第5期75-82,共8页Chinese Journal of Lasers

基　　金：国家自然科学基金(61775140)。

摘　　要：眼轴长度的精确测量对于近视防控、白内障晶体植入术后视力恢复等具有重要意义。本研究团队将Twyman-Green干涉系统与数字信号处理技术相结合,搭建了低相干双光束外差干涉眼轴长度测量系统。为验证该系统的有效性,采用该系统对ZEISS标准模拟眼、人眼分别进行多次测量,进行重复性检验;然后通过统计学分析测量数据的显著性,结果表明差异无统计学意义(P>0.05),符合球形检验;Bland-Altman分析表明,测量数据的95%一致性置信区间均在-0.06~0.06 mm范围内。本系统测量结果与IOLMaster500测量结果具有高度一致性。所设计的眼轴长度测量系统具有良好的有效性和可靠性,为国产眼轴长度测量仪器研发提供了技术方案。Objective The prevalence of myopia in China remains high.Up to 50%of pupils and 90%of teenagers and young adults are myopic,and ametropia is increasingly affecting adolescents and highly educated groups.The development of human eyeballs and the refractive state of both eyes can be evaluated with reference to variation trends in axial length(AL).AL refers to the distance from the front-most surface of the cornea to the retinal pigment epithelium using the optical measurement method.Accurate measurement of eye-axis length is essential for myopia prevention and control and postcataract lens implantation vision recovery.In clinical practice,cataract,refractive error,strabismus,amblyopia,silicone oil-filled macular edema,and other diseases are accompanied by various changes in eye-axis length.Traditional A-or AB-ultrasound requires contact with the eye and is prone to cross-infection,and the measurement is dependent on the operator’s practical experience.Optical AL measurement has the advantages of no contact,high precision,and convenience.In this study,a new AL measurement system(New AL)was built based on an improved Twyman-Green interferometric system,which combines heterodyne interferometry and digital signal processing methods to achieve accurate measurement of AL at low cost,with a simple structure and flexible and convenient operation,providing a technical solution for domestic AL measurement.Methods A low-coherence dual-beam external differential interference ocular AL measurement system based on the Twyman-Green interferometric system was constructed using a 790 nm central wavelength and 30 nm bandwidth laser as the light source(Fig.1).The optical signal was converted to an electrical signal using aualanche photo diode(APD)and passed through the preprocessing circuit,which contained an amplified circuit and long-pass filter circuit.The preprocessing circuit was externally triggered by a data acquisition card(DAQ card)to be acquired as a digital signal,and both the interference signals peak position of anteri

关 键 词：医用光学 眼轴长度 光学相干 Twyman-Green干涉仪 可靠性检测 

分 类 号：TB96[机械工程—光学工程]